精神分裂症患者与健康受试者的异常探索性眼球运动。
Abnormal exploratory eye movements in schizophrenic patients vs healthy subjects.
作者信息
Ryu H, Morita K, Shoji Y, Waseda Y, Maeda H
机构信息
Department of Neuropsychiatry, Kurume University, School of Medicine, Fukuoka, Japan.
出版信息
Acta Neurol Scand. 2001 Dec;104(6):369-76. doi: 10.1034/j.1600-0404.2001.00279.x.
OBJECTIVE
We examined previously described exploratory eye movements abnormalities as biologic markers in schizophrenic patients in comparison with age-matched healthy subjects.
MATERIAL AND METHODS
Using an eye-mark recorder, eye movements were analysed for mean gazing time, total number of gazing points, mean eye scanning length, total eye scanning length, and total gazing times as subjects viewed six simple pictures in preparation for copying them.
RESULTS
In-patients, and to a lesser extent, out-patients, with schizophrenia showed a longer gazing time, fewer gazing points, a shorter mean and total eye scanning length. and longer gazing time than healthy subjects. In schizophrenic patients. negative symptom scores were positively correlated with mean gazing time (r = 0.33), and negatively correlated with the total number of gazing points (r = -0.29) as well as, the mean (r = -0.40) and total scanning length (r = -0.46).
CONCLUSION
Exploratory eye movements are a biologic marker useful for evaluation of schizophrenia.
目的
我们将先前描述的探索性眼球运动异常作为生物学标志物，与年龄匹配的健康受试者相比，对精神分裂症患者进行了研究。
材料与方法
使用眼动记录仪，在受试者观看六张简单图片以准备临摹时，分析其眼球运动的平均注视时间、注视点总数、平均眼扫描长度、总眼扫描长度和总注视次数。
结果
与健康受试者相比，精神分裂症住院患者以及程度稍轻的门诊患者表现出更长的注视时间、更少的注视点、更短的平均和总眼扫描长度，以及更长的注视时间。在精神分裂症患者中，阴性症状评分与平均注视时间呈正相关（r = 0.33），与注视点总数呈负相关（r = -0.29），与平均（r = -0.40）和总扫描长度（r = -0.46）也呈负相关。
结论
探索性眼球运动是一种有助于评估精神分裂症的生物学标志物。
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