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离体角鲨肠道的血管容量-扩张性特征

Vascular volume-distensibility characteristics of the isolated dogfish gut.

作者信息

Opdyke D F, Wilde D W

出版信息

Am J Physiol. 1975 Oct;229(4):1141-6. doi: 10.1152/ajplegacy.1975.229.4.1141.

DOI:10.1152/ajplegacy.1975.229.4.1141
PMID:1190328
Abstract

The vascular capacitance and volume distensibility of the isolated dogfish gut and segments of dogfish arteries and veins were investigated. The volume-distensibility curves for dogfish arteries and veins are very similar to comparable curves derived from arteries and veins of dogs or man. The vascular volume-distensibility curve of the gut, however, shows a greater distensibility at higher systemic pressure than at lower pressure. Evidence is presented that significant amounts of fluid leave the vascular compartment at a lower systemic pressure than in an isolated dog hindlimb preparation. However, this alone does not explain the atypical vascular volume-distensibility curve obtained from the dogfish gut. It is suggested that in the dogfish capillary filtration pore enlargement takes place at a very low capillary pressure or volume (compared to mammals) and this complicates the construction of a volume-distensibility curve because initial vascular volume is not constant.

摘要

对分离的角鲨肠道以及角鲨动脉和静脉段的血管容量和容积扩张性进行了研究。角鲨动脉和静脉的容积扩张性曲线与从狗或人的动脉和静脉得出的类似曲线非常相似。然而,肠道的血管容积扩张性曲线显示,在较高的全身压力下比在较低压力下具有更大的扩张性。有证据表明,与分离的狗后肢标本相比,在较低的全身压力下有大量液体离开血管腔。然而,这 alone 并不能解释从角鲨肠道获得的非典型血管容积扩张性曲线。有人提出,在角鲨中,毛细血管滤过孔在非常低的毛细血管压力或容积下(与哺乳动物相比)就会扩大,这使得容积扩张性曲线的构建变得复杂,因为初始血管容积并不恒定。

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