Nelson P W, Aeder M I, Andrews W, Forster J, Muruve N, Shield C F, Finn J, Bryan C F
Midwest Transplant Network, Westwood, KS 66205, USA.
Clin Transplant. 2001;15 Suppl 6:6-10. doi: 10.1034/j.1399-0012.2001.00001.x.
In view of the influence of donor factors such as age on graft outcome and the performance standards that measure OPO productivity by the number of organs recovered and transplanted, it is important to understand the relationship of certain donor factors on organ recovery for transplantation from cadaveric donors. We examined the influence of donor age, gender and ethnicity on the number and type of transplanted organs recovered from 598 consecutive cadaveric donors in our OPO between 1994 and July 1999. The highest number of organs/donor ocurs in the 11-20 donor age range and declines significantly with each age range. The type of organ recovered is also influenced by age, but the least effect is on liver recovery. No difference was seen in the number of organs recovered/donor by race. When the data were re-analyzed with regard to renal and extra-renal organs transplanted/million donor population, 78% of the kidneys (n=781/1006) were from the 11-50 age range and 81% of the extra-renal organs (n=822/1,192) were from that age range. Stepwise regression yielded a model where donor age significantly influenced (P=0.001) the number of organs recovered. Finally, the incidence of recovered and transplanted organs was significantly higher in males compared with females for hearts [51% (187/360) vs. 40% (86/214); P<0.006] and pancreata [18% (66/360) vs. 11% (24/214); P<0.02]. The number of organs recovered and transplanted from cadaveric organ donors is influenced predominantly by the age of the donor, with the exception being liver donors. Increasing organ recovery and transplantation of organs from donors from the two age extremes results in less gain in the number of organs/million population than recovery from the 11-50 age range.
鉴于供体因素（如年龄）对移植物结果的影响，以及通过回收和移植的器官数量来衡量器官获取组织（OPO）生产力的绩效标准，了解某些供体因素与尸体供体移植器官回收之间的关系非常重要。我们研究了1994年至1999年7月期间，在我们的OPO中，598例连续尸体供体的供体年龄、性别和种族对回收的移植器官数量和类型的影响。每个供体回收的器官数量在11 - 20岁的供体年龄范围内最高，并随着每个年龄范围显著下降。回收的器官类型也受年龄影响，但对肝脏回收的影响最小。按种族分析，每个供体回收的器官数量没有差异。当重新分析关于每百万供体人群中移植的肾脏和肾外器官的数据时，78%的肾脏（n = 781/1006）来自11 - 50岁年龄范围，81%的肾外器官（n = 822/1192）来自该年龄范围。逐步回归得出一个模型，其中供体年龄显著影响（P = 0.001）回收的器官数量。最后，男性回收和移植的心脏[51%（187/360）对40%（86/214）；P < 0.006]和胰腺[18%（66/360）对11%（24/214）；P < 0.02]的发生率明显高于女性。尸体器官供体回收和移植的器官数量主要受供体年龄影响，肝脏供体除外。与从11 - 50岁年龄范围回收相比，从两个年龄极端的供体增加器官回收和移植，每百万人群中器官数量的增加较少。
