Dzoljic E, Sipetic S, Vlajinac H, Marinkovic J, Brzakovic B, Pokrajac M, Kostic V
Institute of Neurology, School of Medicine, University of Belgrade, Belgrade, Yugoslavia.
Headache. 2002 Mar;42(3):185-93. doi: 10.1046/j.1526-4610.2002.02050.x.
To determine prevalence and characteristics of menstrually related migraine and nonmigraine headache in female students of Belgrade University.
A questionnaire was administered to female students during randomly selected classes of the Schools of Medicine and Pharmacy. Diagnoses were assigned according to the criteria of the International Headache Society and MacGregor's stricter definition of "menstrual" migraine.
Of 1943 female students (18 to 28 years old), 1298 (66.8%) had primary headaches. Among 1298 students with headache, 245 (12.6%) had migraine and 1053 (54.2%) had nonmigraine headache. The prevalence rates of migraine versus nonmigraine headache in relation to the menstrual cycle were: premenstrual, 0.9% versus 4.4%; menstrual, 1.5% versus 1.5%; menstrually associated, 6.1% versus 10.1%; menstrually unchanged, 2.7% versus 19.2%; and menstrually unrelated, 1.4% versus 18.9%. Female students with migraine had menstrually related attacks more frequently than students with nonmigraine headache (67.7% versus 29.5%). This difference was most prominent among students with menstrual migraine compared with students with menstrual nonmigraine headache (12.2% versus 2.7%). Exacerbation of migraine during menstruation was slightly more severe and more complex than exacerbation of nonmigraine headache. Female students with migraine versus nonmigraine headache did not differ significantly in age, age at onset of menarche, or age at onset of headache. Female students with migraine were significantly more likely to report a positive family history for migraine and menstrual migraine, severe attacks, reduced work activity, and aura.
The results obtained are in accord with the prevailing opinion that there is a relationship between migraine and female sex hormones, and suggest that women with nonmigraine headache are also susceptible to hormonal fluctuations.
确定贝尔格莱德大学女学生中与月经相关的偏头痛和非偏头痛性头痛的患病率及特征。
在医学院和药学院随机选取的课程中，对女学生进行问卷调查。根据国际头痛协会的标准和麦格雷戈对“月经性”偏头痛更严格的定义进行诊断。
在1943名18至28岁的女学生中，1298名（66.8%）患有原发性头痛。在1298名头痛学生中，245名（12.6%）患有偏头痛，1053名（54.2%）患有非偏头痛性头痛。偏头痛与非偏头痛性头痛在月经周期各阶段的患病率分别为：经前，0.9%对4.4%；经期，1.5%对1.5%；月经相关，6.1%对10.1%；月经无变化，2.7%对19.2%；月经无关，1.4%对18.9%。患有偏头痛的女学生月经相关发作比非偏头痛性头痛的学生更频繁（67.7%对29.5%）。与月经非偏头痛性头痛的学生相比，月经性偏头痛的学生中这种差异最为显著（12.2%对2.7%）。月经期间偏头痛的加重比非偏头痛性头痛的加重略更严重且更复杂。患有偏头痛与非偏头痛性头痛的女学生在年龄、初潮年龄或头痛发病年龄方面无显著差异。患有偏头痛的女学生更有可能报告偏头痛和月经性偏头痛的阳性家族史、严重发作、工作活动减少以及先兆。
所得结果与偏头痛和女性性激素之间存在关联的普遍观点一致，并表明非偏头痛性头痛的女性也易受激素波动影响。
