Vlajinac Hristina D, Dzoljic Eleonora D, Sipetic Sandra B, Kostic Vlada S
Institute of Epidemiology, Belgrade University, School of Medicine, Visegradska 26, 11000 Belgrade, Serbia and Montenegro.
J Neurol. 2004 Aug;251(8):973-6. doi: 10.1007/s00415-004-0474-4.
Various studies have provided evidence that migraine is a multifactorial genetic disorder. The aim of the present study was to compare hereditary patterns of female students with migraine (245 subjects) and non-migraine primary headaches (1053 subjects). The prevalence study was performed combined with a case-control study. Migraineurs had significantly more frequently one or more first-degree and/or second-degree relatives with migraine. Students with menstrual migraine, in comparison with other subtypes of migraine (with the exception of premenstrual migraine), had significantly more frequently > or = 2 relatives with migraine. Among students with non-migraine primary headaches, those with menstrually related headache had more frequently relatives with migraine in comparison with students suffering from menstrually unrelated nonmigraine headache. The results obtained are in line with the results of genetic epidemiologic studies suggesting that genetic factors play a role in the occurrence of migraine.
多项研究已提供证据表明偏头痛是一种多因素遗传疾病。本研究的目的是比较患有偏头痛的女学生（245名受试者）和非偏头痛性原发性头痛的女学生（1053名受试者）的遗传模式。患病率研究与病例对照研究相结合进行。偏头痛患者有一个或多个患偏头痛的一级和/或二级亲属的频率明显更高。与偏头痛的其他亚型（经前偏头痛除外）相比，患有经期偏头痛的学生有≥2名患偏头痛亲属的频率明显更高。在患有非偏头痛性原发性头痛的学生中，与患有与月经无关的非偏头痛性头痛的学生相比，患有与月经相关头痛的学生有偏头痛亲属的频率更高。所获得的结果与遗传流行病学研究的结果一致，表明遗传因素在偏头痛的发生中起作用。
