Gluvić Z, Rasić-Milutinović Z
Klinicko bolnicki centar Zemun/Beograd, 11080 Zemun, Vukova 9.
Med Pregl. 2001 Jul-Aug;54(7-8):383-6.
Pheochromocytoma is an adrenal or extra-adrenal tumor, which produces and secretes catecholamines. It is a rare cause of hypertension. Hypertension or hypertensive crises are most frequent clinical manifestations. Sometimes it can be associated with other diseases and conditions, such as cholelithiasis.
We present a 37-year-old woman admitted to hospital with gastrointestinal complaints (right upper abdominal pain, nausea, vomiting) and hypertension with occasional hypertensive crises. Routine abdominal ultrasound revealed a gall-bladder stone, and enlargement of the right adrenal gland. The diagnosis of pheochromocytoma was confirmed by measurement of catecholamine levels in 24-hour urine collection and MIBG scan. After preoperative preparation, tumor extirpation was done. Histology confirmed the diagnosis of pheochromocytoma. Routine controls of catecholamine 24-hour urine levels showed no catecholamine excess, without hypertension and hypertensive crises as most frequent clinical manifestations.
Physicians must consider pheochromocytomas in cases of drug resistant hypertension or hypertensive crises. Sometimes pheochromocytomas are associated with other diseases, such as gall-bladder stones, with mimicking and overlapping of clinical manifestations of pheochromocytomas with symptoms and signs of the associated disease.
嗜铬细胞瘤是一种肾上腺或肾上腺外肿瘤，可产生和分泌儿茶酚胺。它是高血压的罕见病因。高血压或高血压危象是最常见的临床表现。有时它可与其他疾病和病症相关，如胆结石。
我们报告一名37岁女性，因胃肠道不适（右上腹疼痛、恶心、呕吐）及高血压伴偶发高血压危象入院。常规腹部超声显示胆囊结石及右肾上腺增大。通过检测24小时尿儿茶酚胺水平及间碘苄胍扫描确诊为嗜铬细胞瘤。经术前准备后进行了肿瘤切除。组织学检查证实为嗜铬细胞瘤。24小时尿儿茶酚胺水平的常规监测显示无儿茶酚胺过量，无高血压及高血压危象等最常见临床表现。
对于药物抵抗性高血压或高血压危象病例，医生必须考虑嗜铬细胞瘤。有时嗜铬细胞瘤与其他疾病相关，如胆结石，其临床表现与相关疾病的症状和体征存在相似和重叠。
