Pasquier C, Auscher C, Pehuet P, Delbarre F
Ann Biol Clin (Paris). 1975;33(1):15-9.
Oxithiopurinol, [4-thio-6-hydroxypyrazolo(3,4-d)pyrimidine] has been caracterized in urines of patients treated with Thiopurinol : the principle involved is the precipitation of both oxithiopurinol and uric acid in combination with cupric hydroxide. The urinary oxithopurinol content is determined by means of anion and cation exchange resins. 56 to 70 per cent of the daily dose of Thiopurinol are eliminated in urine as oxithiopurinol.
氧硫嘌呤醇，[4-硫代-6-羟基吡唑并(3,4-d)嘧啶]已在接受硫嘌呤醇治疗的患者尿液中得到鉴定：所涉及的原理是氧硫嘌呤醇和尿酸与氢氧化铜结合沉淀。尿中氧硫嘌呤醇的含量通过阴离子和阳离子交换树脂来测定。硫嘌呤醇每日剂量的56%至70%以氧硫嘌呤醇的形式经尿液排出。
