Targowski S P, Berman D T
Am J Vet Res. 1975 Nov;36(11):1561-5.
Injection of mammary glands of cows with heat-killed staphylococcal cells, staphylococcal cell walls, or distilled water induced leukocytosis. The magnitude of leukocytic response to staphylococcal antigens in cows of each treatment group depended on the extent of previous experience with staphylococcal cell materials. The 2nd intramammary injection produced greater reactions than did the 1st, and the 1st injection in cows previously parenterally vaccinated with killed cells in oil-water adjuvant produced responses comparable with those elicited by the 2nd intramammary injection in nonvaccinated cows. The implications that these changes have toward understanding the pathogenesis of, and immunity to, staphylococcal mastitis were discussed.
给奶牛乳腺注射热杀死的葡萄球菌细胞、葡萄球菌细胞壁或蒸馏水可引起白细胞增多。每个治疗组奶牛对葡萄球菌抗原的白细胞反应程度取决于先前接触葡萄球菌细胞物质的程度。第二次乳房内注射产生的反应比第一次更大，并且在先前用油水佐剂中灭活细胞进行过肠胃外疫苗接种的奶牛中，第一次注射产生的反应与未接种疫苗的奶牛第二次乳房内注射所引发的反应相当。讨论了这些变化对理解葡萄球菌性乳腺炎的发病机制和免疫的意义。
