Robinson G R, Wagstaff D J, Colaianne J J, Ulsamer A G
Am J Vet Res. 1975 Nov;36(11):1615-8.
Hexachlorophene (HCP) intoxication in swine was studied as a possible model of HCP poisoning in human beings. Swine were topically or orally given HCP each day, and observations were made on central nervous system function, hematologic measurements, serum chemical analyses, necropsy, microscopic examination of tissues, and concentrations of HCP residues in blood and tissue. Intoxication was observed in orally exposed swine, but the syndrome was not consistently produced in topically exposed swine. Signs and microscopic lesions were all related to dysfunction of the central nervous system, e.g., incoordination, paresis, and status spongiosus. Occurrence of signs and lesions, mortality rates, and concentrations of HCP residue were positively correlated with the dosage of HCP given.
对猪的六氯酚（HCP）中毒进行了研究，以作为人类HCP中毒的一种可能模型。每天给猪局部或口服HCP，并对中枢神经系统功能、血液学测量、血清化学分析、尸检、组织显微镜检查以及血液和组织中HCP残留浓度进行观察。在口服接触HCP的猪中观察到中毒现象，但在局部接触HCP的猪中并未始终出现该综合征。体征和微观病变均与中枢神经系统功能障碍有关，例如共济失调、轻瘫和海绵状态。体征和病变的出现、死亡率以及HCP残留浓度与所给予的HCP剂量呈正相关。
