地塞米松对白化大鼠着床和妊娠的影响。

Effect of dexamethasone on implantation and pregnancy in albino rats.

作者信息

Nevagi S A, Kaliwal B B

机构信息

Postgraduate Department of Studies in Zoology, Karnatak University, Dharwad, India.

出版信息

Indian J Exp Biol. 2001 Nov;39(11):1163-5.

PMID:11906112

Abstract

Administration of 3 mg/kg body weight of dexamethasone from day 1 or 3 to 7 of pregnancy did not prevent implantation in albino rats. But the same dose when administered from day 8 to 11 resulted in complete abortion / resorption in all rats. Administration of 2 mg / kg body weight of dexamethasone from day 8 to 11 of pregnancy held no effect on the foetal survival. The results indicate that a high dose of dexamethasone does not affect implantation but the same dose affects the more advanced stages of pregnancy.

摘要

从妊娠第1天或第3天至第7天给予3毫克/千克体重的地塞米松，对白化大鼠的着床没有预防作用。但从第8天至第11天给予相同剂量，则导致所有大鼠完全流产/吸收。从妊娠第8天至第11天给予2毫克/千克体重的地塞米松，对胎儿存活没有影响。结果表明，高剂量的地塞米松不影响着床，但相同剂量会影响妊娠的更后期阶段。