Ikäheimo Kirsi, Kettunen Raimo, Mäntyjärvi Maija
Department of Ophthalmology, University Hospital of Kuopio, Kuopio, Finland.
Acta Ophthalmol Scand. 2002 Feb;80(1):59-63. doi: 10.1034/j.1600-0420.2002.800112.x.
To study visual functions and ocular adverse effects of long-term amiodarone medication.
We performed an eye examination of 22 patients with long-term amiodarone medication. In addition to corrected visual acuity, colour vision was studied with the Standard Pseudoisochromatic Plates part 2 and Farnsworth-Munself 100 hue test. Contrast sensitivity was examined with the Pelli-Robson chart. Visual fields were tested by Goldmann and Friedmann perimetry.
Two patients with otherwise healthy eyes had abnormal blue colour vision test results. Otherwise colour vision, contrast sensitivity, and visual field test results were within normal range or could be explained by eye diseases such as cataract. Corneal drug deposits were found in 100% of the examined eyes. Slight anterior subcapsular lens opacities were found in 22.2%. Dry eyes were diagnosed in 9.1%. The eye fundi did not reveal any abnormalities that could be thought of as caused by amiodarone.
The slight blue colour vision defect found in two patients with otherwise healthy eyes might represent an early sign of the optic nerve impairment which is a rare complication of amiodarone medication. The number of corneal and lens changes as well as dry eyes were found at levels previously described.
研究长期服用胺碘酮的视觉功能及眼部不良反应。
我们对22例长期服用胺碘酮的患者进行了眼部检查。除矫正视力外，还用标准假同色表第2部分和法恩斯沃思-芒塞尔100色调试验研究了色觉。用佩利-罗布森图表检查对比敏感度。用戈德曼和弗里德曼视野计测试视野。
两名眼部其他方面健康的患者色觉测试结果异常。其他方面，色觉、对比敏感度和视野测试结果在正常范围内，或可由白内障等眼部疾病解释。100%的受检眼发现角膜药物沉积。22.2%发现轻微的前囊下晶状体混浊。9.1%诊断为干眼症。眼底未发现任何可认为是由胺碘酮引起的异常。
两名眼部其他方面健康的患者中发现的轻微蓝色色觉缺陷可能代表视神经损害的早期迹象，这是胺碘酮用药的一种罕见并发症。角膜和晶状体变化以及干眼症的数量与先前描述的水平一致。
