Berglund B, Gennser M, Ornhagen H, Ostberg C, Wide L
Division of Medicine, Karolinska Hospital, Stockholm, Sweden.
Acta Physiol Scand. 2002 Mar;174(3):225-9. doi: 10.1046/j.1365-201x.2002.00940.x.
Serum erythropoietin levels (s-[epo]), haemoglobin concentration ([Hb]), haematocrit (hct), and ferritin concentration ([fer]) were measured in seven healthy male volunteers (20-23 years) exposed continuously to hypoxia (PO(2) 14 kPa) for 10 days. Serum erythropoietin concentration increased significantly from 9.5 +/- 3.51 to 33.6 +/- 11.64 U L(-1) (P < 0.05) after 2 days of hypoxia. Thereafter, s-[epo] decreased. However, after 10 days s-[epo] was 18.7 +/- 5.83 U L(-1) which was still increased above the pre-hypoxia level (P < 0.05). Serum haemoglobin concentration and hct increased over the 10 days of hypoxia, [Hb] from 152 +/- 8.9 to 168 +/- 9.2 gL(-1) (P < 0.001), and hct from 43 +/- 2.4 to 49 +/- 2.6% (P < 0.001). Ferritin concentration decreased significantly during the hypoxic exposure from 82 +/- 46.9 to 44 +/- 31.7 mmol L(-1) after 10 days (P < 0.01). In conclusion, the initial increase of s-[epo] under controlled normobaric hypoxia was marked, 353%, and levelled off after 5-10 days at 62-97% above normoxia level. There was also a significant increase in [Hb] and hct and a decrease in [fer] after 10 days of exposure to normobaric hypoxia.
对7名年龄在20 - 23岁的健康男性志愿者进行连续10天的低氧暴露（PO₂ 14 kPa），并测量其血清促红细胞生成素水平（s-[epo]）、血红蛋白浓度（[Hb]）、血细胞比容（hct）和铁蛋白浓度（[fer]）。低氧暴露2天后，血清促红细胞生成素浓度从9.5±3.51显著增加至33.6±11.64 U L⁻¹（P < 0.05）。此后，s-[epo]下降。然而，10天后s-[epo]为18.7±5.83 U L⁻¹，仍高于低氧暴露前水平（P < 0.05）。在10天的低氧暴露期间，血清血红蛋白浓度和hct升高，[Hb]从152±8.9升高至168±9.2 gL⁻¹（P < 0.001），hct从43±2.4升高至49±2.6%（P < 0.001）。在低氧暴露期间，铁蛋白浓度在10天后从82±46.9显著降至44±31.7 mmol L⁻¹（P < 0.01）。总之，在控制性常压低氧条件下，s-[epo]的初始升高显著，为353%，并在5 - 10天后稳定在高于常氧水平62 - 97%。在常压低氧暴露10天后，[Hb]和hct也显著升高，[fer]降低。
