Enrique E, Cisteró-Bahíma A, Bartolomé B, Alonso R, San Miguel-Moncín M M, Bartra J, Martínez A
Allergy Department, Institut Universitari Dexeus, Barcelona, Spain.
Allergy. 2002 Apr;57(4):351-6. doi: 10.1034/j.1398-9995.2002.1s3509.x.
In Mediterranean areas, oral allergy syndrome (OAS) occurs independently of an associated birch pollinosis; moreover, on occasions it presents with no other associated pollinosis. The aim of this study was to assess the possible association of OAS with Platanus acerifolia pollinosis.
We evaluated consecutive patients seen for pollinosis in an allergy department. Seven hundred and twenty patients were selected on the basis of seasonal or perennial rhinitis, or asthma, or both. Respiratory and food allergies were studied in all patients. Clinical history was recorded and examinations and skin prick tests were performed with a battery of available common inhalant allergens and plant-derived food allergens. Specific IgE levels to P. acerifolia pollen extract and food allergens tested were measured. Molecular masses of the IgE-binding proteins and cross-reactivity among the P. acerifolia pollen and different food extracts were also determined.
Of the 720 patients evaluated, 61 (8.48%) were sensitized to P. acerifolia pollen. Food allergy was observed in 32 (52.45%) of the 61 patients sensitized to P. acerifolia pollen. Food allergens most frequently implicated were hazelnuts, peach, apple, peanuts, maize, chickpea and lettuce. Enzyme allergosorbent (EAST)-inhibition showed high inhibition values when P. acerifolia pollen extract was used as free phase. On the contrary low inhibition was observed when plant-derived food allergens were used as free phase and P. acerifolia pollen extract as solid phase.
Cross-reactivity was observed among P. acerifolia pollen and plant-derived foods. OAS in these patients may have been caused by primary respiratory sensitization.
在地中海地区，口腔过敏综合征（OAS）独立于相关的桦树花粉症而发生；此外，有时它并无其他相关的花粉症。本研究的目的是评估OAS与悬铃木花粉症之间可能存在的关联。
我们评估了过敏科因花粉症前来就诊的连续患者。根据季节性或常年性鼻炎、哮喘或两者兼有，选择了720例患者。对所有患者进行了呼吸道和食物过敏研究。记录临床病史，并使用一系列现有的常见吸入性变应原和植物源性食物变应原进行检查和皮肤点刺试验。测定了针对悬铃木花粉提取物和所检测食物变应原的特异性IgE水平。还确定了IgE结合蛋白的分子量以及悬铃木花粉与不同食物提取物之间的交叉反应性。
在评估的720例患者中，61例（8.48%）对悬铃木花粉致敏。在61例对悬铃木花粉致敏的患者中，32例（52.45%）存在食物过敏。最常涉及的食物变应原是榛子、桃子、苹果、花生、玉米、鹰嘴豆和生菜。当使用悬铃木花粉提取物作为游离相时，酶联免疫吸附试验（EAST）抑制显示出高抑制值。相反，当使用植物源性食物变应原作为游离相且悬铃木花粉提取物作为固相时，观察到低抑制。
观察到悬铃木花粉与植物源性食物之间存在交叉反应。这些患者的OAS可能是由原发性呼吸道致敏引起的。
