David Hélène N, Abraini Jacques H
UMR CNRS 6551, Centre CYCERON, BP 5229, Université de Caen Basse-Normandie, Boulevard Henri Becquerel, 14074 Caen cedex, France.
Eur J Neurosci. 2002 Mar;15(5):869-75. doi: 10.1046/j.1460-9568.2002.01919.x.
Evidence for functional interactions between metabotropic glutamate (mGlu) receptors and dopamine (DA) neurotransmission is now clearly established. In the present study, we investigated interactions between group III mGlu receptors and D1- and D2-like receptors in the nucleus accumbens (NAcc). Administration, into the NAcc, of the selective group III mGlu receptor agonist, AP4, resulted in an increase in locomotor activity, which was blocked by pretreatment with the group III mGlu receptor antagonist, MPPG. In addition, pretreatment with AP4 further blocked the increase in motor activity induced by the D1-like receptor agonist, SKF 38393, but potentiated the locomotor responses induced by either the D2-like receptor agonist, quinpirole, or coinfusion of SKF 38393 and quinpirole. MPPG reversed the effects of AP4 on the motor responses induced by D1-like and/or D2-like receptor activation. These results confirm that glutamate transmission may control DA-dependent locomotor function through mGlu receptors and further indicate that group III mGlu receptors oppose the behavioural response produced by D1-like receptor activation and favour those produced by D2-like receptor activation.
代谢型谷氨酸（mGlu）受体与多巴胺（DA）神经传递之间功能相互作用的证据现已明确确立。在本研究中，我们调查了伏隔核（NAcc）中III组mGlu受体与D1样和D2样受体之间的相互作用。向NAcc注射选择性III组mGlu受体激动剂AP4会导致运动活性增加，而这种增加会被III组mGlu受体拮抗剂MPPG预处理所阻断。此外，AP4预处理进一步阻断了D1样受体激动剂SKF 38393诱导的运动活性增加，但增强了D2样受体激动剂喹吡罗或SKF 38393与喹吡罗共同注射所诱导的运动反应。MPPG逆转了AP4对D1样和/或D2样受体激活所诱导的运动反应的影响。这些结果证实谷氨酸传递可能通过mGlu受体控制DA依赖的运动功能，并进一步表明III组mGlu受体对抗D1样受体激活产生的行为反应，而有利于D2样受体激活产生的行为反应。
