Lepistö P, Avikainen V, Alho A, Jäättelä A, Karaharju E, Kataja J, Lahdensuu M, Rokkanen P, Tervo T
Ann Chir Gynaecol Fenn. 1975;64(4):198-202.
Forty-five patients with severe blunt injuries were examined during eight posttraumatic days. At random, 14 patients were given three doses of methylprednisolone intravenously; 10 mg/kg at 8-hour intervals. Fat embolism syndrome was diagnosed in 13/45 patients, only one of whom had received corticosteroid (p = 0.03). Shock, acidosis and elevated plasma catecholamines showed no correlation with the occurrence of fat embolism syndrome. Platelet counts immediately after trauma were significantly lower in the fat embolism patients than in the other trauma patients, indicative of early platelet aggregation. Prophylactically administered methylprednisolone in pharmacological doses appeared to inhibit the emergence of fat embolism syndrome.
在创伤后的八天内，对45例严重钝性损伤患者进行了检查。随机选取14例患者静脉注射三剂甲基强的松龙，每8小时一次，剂量为10mg/kg。45例患者中有13例被诊断为脂肪栓塞综合征，其中只有1例接受了皮质类固醇治疗（p = 0.03）。休克、酸中毒和血浆儿茶酚胺升高与脂肪栓塞综合征的发生无相关性。脂肪栓塞患者创伤后即刻的血小板计数显著低于其他创伤患者，提示早期血小板聚集。预防性给予药理剂量的甲基强的松龙似乎可抑制脂肪栓塞综合征的出现。
