Pasqualini J R, Chaudhuri S, Nguyen B L
Ann Endocrinol (Paris). 1975 Mar-Apr;36(2):97-8.
The physiological significance of a new steroid: the 3beta, 21-dihydroxy-5alpha-pregnan-20-one (3beta,5alpha-tetrahydro-DOC) was studied during human pregnancy. The urinary excretion values in the first and second trimester of pregnancy are 100-400 mug/24 h and in the third trimester the values increase to 240-1080 mug/24 h. This compound is not found in men nor in non-pregnant women but is found in the urine of newborns (2-12 DAYS): 25-80 mug/24 h. After perfusion of the fetus with H-deoxycorticosterone, 3H-3beta, 5alpha-tetrahydro-DOC was found in the fetal liver. These data suggest that this steroid could originate in the fetus: parallel studies of the urinary excretion of the other isomer : 3alpha821 dihydroxy-5beta-pregnan-20-one (3alpha,5beta-tetrahydro-DOC) shows that this compound increases at the end of pregnancy but its excretion rate is 2-3 times less than that of 3beta, 5alpha-tetrahydro-DOC.
3β,21-二羟基-5α-孕烷-20-酮（3β,5α-四氢脱氧皮质酮）在人类孕期的生理意义得到了研究。孕期头三个月和第二个三个月的尿排泄值为100 - 400微克/24小时，而在第三个三个月，该值增至240 - 1080微克/24小时。在男性和未孕女性尿液中未发现这种化合物，但在新生儿（2 - 12天）尿液中可检测到：25 - 80微克/24小时。用H-脱氧皮质酮灌注胎儿后，在胎儿肝脏中发现了3H-3β,5α-四氢脱氧皮质酮。这些数据表明这种甾体激素可能源自胎儿：对另一种异构体3α,21-二羟基-5β-孕烷-20-酮（3α,5β-四氢脱氧皮质酮）尿排泄的平行研究显示，这种化合物在孕期结束时增加，但其排泄率比3β,5α-四氢脱氧皮质酮低2 - 3倍。
