潜伏性爱泼斯坦-巴尔病毒基因组的即刻早期启动子Zp和Rp以及oriLyt的核蛋白结构
Nucleoprotein structure of immediate-early promoters Zp and Rp and of oriLyt of latent Epstein-Barr virus genomes.
作者信息
Niller Hans Helmut, Salamon Daniel, Uhlig Jörg, Ranf Stefanie, Granz Marcus, Schwarzmann Fritz, Wolf Hans, Minarovits Janos
机构信息
Institut für Medizinische Mikrobiologie und Hygiene, Universität Regensburg, D-93053 Regensburg, Germany.
出版信息
J Virol. 2002 Apr;76(8):4113-8. doi: 10.1128/jvi.76.8.4113-4118.2002.
Abstract
Genomic footprints across Rp, Zp, and oriLyt of Epstein-Barr virus (EBV) have been conducted in a panel of latently infected B-cell lines. Close protein-base contacts were found about 360 nucleotides upstream of the Zp initiation site. Gel shifts and transient transfection assays indicated that an Sp1-NF1 locus may serve as a repressive transcriptional element against Zp induction from latent EBV genomes.
摘要
在一组潜伏感染的B细胞系中，对爱泼斯坦-巴尔病毒（EBV）的Rp、Zp和oriLyt进行了基因组足迹分析。在Zp起始位点上游约360个核苷酸处发现了紧密的蛋白质-碱基接触。凝胶迁移和瞬时转染分析表明，一个Sp1-NF1位点可能作为一个抑制性转录元件，抑制潜伏EBV基因组中Zp的诱导。
相似文献
1
Nucleoprotein structure of immediate-early promoters Zp and Rp and of oriLyt of latent Epstein-Barr virus genomes.潜伏性爱泼斯坦-巴尔病毒基因组的即刻早期启动子Zp和Rp以及oriLyt的核蛋白结构
J Virol. 2002 Apr;76(8):4113-8. doi: 10.1128/jvi.76.8.4113-4118.2002.
2
EBV-immortalized isogenic human B-cell clones exhibit differences in DNA-protein complex formation on the BZLF1 and BRLF1 promoter regions among latent, lytic and TPA-activated cell lines.EBV永生化的同基因人类B细胞克隆在潜伏、裂解和TPA激活的细胞系中，在BZLF1和BRLF1启动子区域的DNA-蛋白质复合物形成方面表现出差异。
Virus Res. 1994 Jan;31(1):89-107. doi: 10.1016/0168-1702(94)90073-6.
3
Cellular differentiation regulator BLIMP1 induces Epstein-Barr virus lytic reactivation in epithelial and B cells by activating transcription from both the R and Z promoters.细胞分化调节因子BLIMP1通过激活R和Z启动子的转录，诱导上皮细胞和B细胞中的爱泼斯坦-巴尔病毒裂解性再激活。
J Virol. 2015 Feb;89(3):1731-43. doi: 10.1128/JVI.02781-14. Epub 2014 Nov 19.
4
High-resolution methylation analysis and in vivo protein-DNA binding at the promoter of the viral oncogene LMP2A in B cell lines carrying latent Epstein-Barr virus genomes.在携带潜伏性爱泼斯坦-巴尔病毒基因组的B细胞系中，对病毒癌基因LMP2A启动子进行高分辨率甲基化分析及体内蛋白质-DNA结合分析。
Virus Genes. 2003 Aug;27(1):57-66. doi: 10.1023/a:1025124519068.
5
LMP1-Induced Sumoylation Influences the Maintenance of Epstein-Barr Virus Latency through KAP1.LMP1诱导的类泛素化修饰通过KAP1影响爱泼斯坦-巴尔病毒潜伏感染的维持。
J Virol. 2015 Aug;89(15):7465-77. doi: 10.1128/JVI.00711-15. Epub 2015 May 6.
6
Epstein-Barr virus (EBV) EB1/Zta protein provided in trans and competent for the activation of productive cycle genes does not activate the BZLF1 gene in the EBV genome.反式提供且能够激活增殖周期基因的爱泼斯坦-巴尔病毒（EBV）EB1/Zta蛋白不会激活EBV基因组中的BZLF1基因。
J Gen Virol. 1996 Mar;77 ( Pt 3):501-9. doi: 10.1099/0022-1317-77-3-501.
7
Autostimulation of the Epstein-Barr virus BRLF1 promoter is mediated through consensus Sp1 and Sp3 binding sites.爱泼斯坦-巴尔病毒BRLF1启动子的自刺激是通过共有Sp1和Sp3结合位点介导的。
J Virol. 2001 Jun;75(11):5240-51. doi: 10.1128/JVI.75.11.5240-5251.2001.
8
Epstein-Barr virus immediate-early proteins BZLF1 and BRLF1 activate the ATF2 transcription factor by increasing the levels of phosphorylated p38 and c-Jun N-terminal kinases.爱泼斯坦-巴尔病毒即刻早期蛋白BZLF1和BRLF1通过提高磷酸化p38和c-Jun氨基末端激酶的水平来激活ATF2转录因子。
J Virol. 2000 Feb;74(3):1224-33. doi: 10.1128/jvi.74.3.1224-1233.2000.
9
Methylation of Epstein-Barr virus Rta promoter in EBV primary infection, reactivation and lymphoproliferation.EBV 原发性感染、再激活和淋巴组织增生中 EB 病毒 Rta 启动子的甲基化。
J Med Virol. 2016 Oct;88(10):1814-20. doi: 10.1002/jmv.24524. Epub 2016 Mar 28.
10
Protein kinase C-independent activation of the Epstein-Barr virus lytic cycle.不依赖蛋白激酶C激活爱泼斯坦-巴尔病毒裂解周期
J Virol. 2002 Jun;76(11):5612-26. doi: 10.1128/jvi.76.11.5612-5626.2002.
引用本文的文献
1
Analysis of an ankyrin-like region in Epstein Barr Virus encoded (EBV) BZLF-1 (ZEBRA) protein: implications for interactions with NF-κB and p53.分析 Epstein Barr 病毒编码（EBV）BZLF-1（ZEBRA）蛋白中的锚蛋白样区域：对与 NF-κB 和 p53 相互作用的影响。
Virol J. 2011 Sep 5;8:422. doi: 10.1186/1743-422X-8-422.
2
Histone hyperacetylation occurs on promoters of lytic cycle regulatory genes in Epstein-Barr virus-infected cell lines which are refractory to disruption of latency by histone deacetylase inhibitors.组蛋白高度乙酰化发生在爱泼斯坦-巴尔病毒感染的细胞系中裂解周期调节基因的启动子上，这些细胞系对组蛋白脱乙酰酶抑制剂破坏潜伏期具有抗性。
J Virol. 2008 May;82(10):4706-19. doi: 10.1128/JVI.00116-08. Epub 2008 Mar 12.
3
High-resolution analysis of CpG methylation and in vivo protein-DNA interactions at the alternative Epstein-Barr virus latency promoters Qp and Cp in the nasopharyngeal carcinoma cell line C666-1.对鼻咽癌细胞系C666-1中爱泼斯坦-巴尔病毒潜伏性启动子Qp和Cp处的CpG甲基化及体内蛋白质-DNA相互作用进行高分辨率分析。
Virus Genes. 2007 Oct;35(2):195-202. doi: 10.1007/s11262-007-0095-y. Epub 2007 May 18.
4
Activation of Epstein-Barr virus by saliva from Sjogren's syndrome patients.干燥综合征患者唾液激活爱泼斯坦-巴尔病毒
Immunology. 2004 Feb;111(2):223-9. doi: 10.1111/j.0019-2805.2003.01795.x.
5
ZEB negatively regulates the lytic-switch BZLF1 gene promoter of Epstein-Barr virus.ZEB负向调控爱泼斯坦-巴尔病毒的裂解开关BZLF1基因启动子。
J Virol. 2003 Jan;77(1):199-207. doi: 10.1128/jvi.77.1.199-207.2003.
本文引用的文献
1
Protein-DNA interaction and CpG methylation at rep*/vIL-10p of latent Epstein-Barr virus genomes in lymphoid cell lines.淋巴母细胞系中潜伏性爱泼斯坦-巴尔病毒基因组rep*/vIL-10p处的蛋白质-DNA相互作用及CpG甲基化
Biol Chem. 2001 Oct;382(10):1411-9. doi: 10.1515/BC.2001.174.
2
Epigenetics of latent Epstein-Barr virus genomes: high resolution methylation analysis of the bidirectional promoter region of latent membrane protein 1 and 2B genes.
Biol Chem. 2001 Apr;382(4):699-705. doi: 10.1515/BC.2001.083.
3
Autostimulation of the Epstein-Barr virus BRLF1 promoter is mediated through consensus Sp1 and Sp3 binding sites.爱泼斯坦-巴尔病毒BRLF1启动子的自刺激是通过共有Sp1和Sp3结合位点介导的。
J Virol. 2001 Jun;75(11):5240-51. doi: 10.1128/JVI.75.11.5240-5251.2001.
4
Protein-DNA binding and CpG methylation at nucleotide resolution of latency-associated promoters Qp, Cp, and LMP1p of Epstein-Barr virus.爱泼斯坦-巴尔病毒潜伏相关启动子Qp、Cp和LMP1p在核苷酸分辨率下的蛋白质-DNA结合及CpG甲基化
J Virol. 2001 Mar;75(6):2584-96. doi: 10.1128/JVI.75.6.2584-2596.2001.
5
Identification of a novel element involved in regulation of the lytic switch BZLF1 gene promoter of Epstein-Barr virus.鉴定一种参与调控爱泼斯坦-巴尔病毒裂解开关BZLF1基因启动子的新元件。
J Virol. 2001 Jan;75(2):867-77. doi: 10.1128/JVI.75.2.867-877.2001.
6
The TRANSFAC system on gene expression regulation.关于基因表达调控的TRANSFAC系统。
Nucleic Acids Res. 2001 Jan 1;29(1):281-3. doi: 10.1093/nar/29.1.281.
7
Lytic but not latent replication of epstein-barr virus is associated with PML and induces sequential release of nuclear domain 10 proteins.爱泼斯坦-巴尔病毒的裂解而非潜伏性复制与早幼粒细胞白血病蛋白相关，并诱导核域10蛋白的顺序释放。
J Virol. 2000 Dec;74(24):11800-10. doi: 10.1128/jvi.74.24.11800-11810.2000.
8
Activation of the BRLF1 promoter and lytic cycle of Epstein-Barr virus by histone acetylation.组蛋白乙酰化对爱泼斯坦-巴尔病毒BRLF1启动子的激活及裂解周期
Nucleic Acids Res. 2000 Oct 15;28(20):3918-25. doi: 10.1093/nar/28.20.3918.
9
Histone acetylation and reactivation of Epstein-Barr virus from latency.组蛋白乙酰化与爱泼斯坦-巴尔病毒从潜伏状态的重新激活
J Virol. 2000 Jan;74(2):710-20. doi: 10.1128/jvi.74.2.710-720.2000.
10
Demethylation of the Epstein-barr virus origin of lytic replication and of the immediate early gene BZLF1 is DNA replication independent. Brief report.
Arch Virol. 1999;144(11):2219-27. doi: 10.1007/s007050050636.
Zotero 插件