Fragu P, Comoy E, Nataf B
Ann Endocrinol (Paris). 1975 May-Jun;36(3):165-6.
Peroxydase activity in various benign thyroid diseases has been investigated. In hyperthyroid patients treated with antithyroid drugs, the observed increase in iodide-peroxydase activity (7 times that of normal tissue) is double than that of the DNA content. In goiter, the activity is 3 times that of normal tissue while the DNA content is unchanged. These results are in agreement with those obtained in rats maintained on a low iodine diet suggesting that high cellular enzymatic activity is due to specific enzyme induction in excess of cell proliferation and protein synthesis.
对各种良性甲状腺疾病中的过氧化物酶活性进行了研究。在用抗甲状腺药物治疗的甲状腺功能亢进患者中，观察到的碘过氧化物酶活性增加（是正常组织的7倍）是DNA含量增加的两倍。在甲状腺肿中，该活性是正常组织的3倍，而DNA含量不变。这些结果与在低碘饮食喂养的大鼠中获得的结果一致，表明高细胞酶活性是由于细胞增殖和蛋白质合成过量导致的特定酶诱导。
