Khanna N, Brooks S E, Chen T T, Simsir A, Gordon N J, Taylor G
Department of Family Medicine, University of Maryland School of Medicine and Greenebaum Cancer Center, Baltimore, Maryland 21201, USA.
J Hum Virol. 2001 Sep-Oct;4(5):283-7.
We studied the role of human papillomavirus (HPV) typing in predicting cervical dysplasia in women with abnormal Papanicolaou (Pap) test results.
STUDY DESIGN/METHODS: A university colposcopy clinic-based consecutive sample of 179 women completed a questionnaire and underwent colposcopy, HPV typing (Hybrid Capture System HPV DNA Assay II; Digene Diagnostics, Gaithersburg, MD, USA), and biopsy (if indicated).
No severe dysplasia was observed in women with low-risk HPV or in women with negative HPV test results who had a low-grade abnormality on the Pap test. High-risk (HR) HPV was present in every case of severe dysplasia on biopsy. The cumulative odds risk for cervical dysplasia was 1.11 in HIV(+) women with low-grade squamous intraepithelial lesion on the Pap test who were older than 21 years of age and HPV-HR(+).
In the population studied, HPV typing is a valuable adjunct to a low-grade abnormality on the Pap test in predicting the absence of cervical dysplasia on biopsy. Larger prospective population-based studies are needed to study the role of HPV as a negative predictor of disease in cervical dysplasia.
我们研究了人乳头瘤病毒（HPV）分型在预测巴氏涂片检查结果异常女性宫颈发育异常中的作用。
研究设计/方法：以大学阴道镜诊所为基础，对179名女性进行连续抽样，她们均完成了问卷调查，并接受了阴道镜检查、HPV分型（杂交捕获系统HPV DNA检测II；美国马里兰州盖瑟斯堡的Digene诊断公司）以及活检（如有必要）。
在HPV检测为低风险的女性或巴氏涂片检查有低度异常但HPV检测结果为阴性的女性中，未观察到严重发育异常。活检确诊的每一例严重发育异常病例中均检测到高危（HR）HPV。在巴氏涂片检查有低度鳞状上皮内病变、年龄超过21岁且HPV-HR（+）的HIV（+）女性中，宫颈发育异常的累积比值风险为1.11。
在所研究的人群中，HPV分型对于预测巴氏涂片检查低度异常女性活检时无宫颈发育异常是一项有价值的辅助手段。需要开展更大规模基于人群的前瞻性研究，以探讨HPV作为宫颈发育异常疾病阴性预测指标的作用。
