Sanada M, Nakagawa H, Kodama I, Sakasita T, Ohama K
Department of Obstetrics and Gynecology, Hiroshima University School of Medicine, Hiroshima, Japan.
Climacteric. 1998 Sep;1(3):188-95. doi: 10.3109/13697139809085540.
The aim of the study was to investigate the effects of apolipoprotein E (apo E) phenotype on plasma lipids and bone mass in postmenopausal Japanese women.
In 320 subjects aged 40-65 years (mean +/- SE, 54.0 +/- 0.6), apo E phenotype was determined by isometric electrophoresis. Phenotypic frequencies were 0.3% for E2/2 (n = 1), 8.1% for E3/2 (n = 26), 70.3% for E3/3 (n = 225), 0.6% for E4/2 (n = 2), 19.4% for E4/3 (n = 62) and 1.3% for E4/4 (n = 4). Apo E2/2 and apo E3/2 were classified as E2+ (n = 27); apo E3 homozygotes were placed in another group (E3/3; n = 225), as were apo E4/3 together with apo E4/4 subjects (group E4+; n = 66). Bone density and bone quality were assessed with a newly developed ultrasonic bone densitometer, and plasma lipids were also measured.
Age, body mass index and years since menopause did not differ significantly between the three groups. The E4+ group had the highest levels of total cholesterol, low-density lipoprotein cholesterol and apolipoprotein B, significantly higher than in the E2+ group. Plasma lipoprotein(a) concentrations were significantly higher in the E4+ group than in the other two groups. Ultrasonic parameters of bone density and quality tended to be lower in the E4+ group than in the E2+ group.
The apo E4 allele was associated with high plasma cholesterol levels and an unfavorable change of bone structure in postmenopausal women.
本研究旨在探讨载脂蛋白E（apo E）表型对绝经后日本女性血脂和骨量的影响。
在320名年龄在40 - 65岁（平均±标准误，54.0±0.6）的受试者中，通过等距电泳确定apo E表型。表型频率分别为：E2/2为0.3%（n = 1），E3/2为8.1%（n = 26），E3/3为70.3%（n = 225），E4/2为0.6%（n = 2），E4/3为19.4%（n = 62），E4/4为1.3%（n = 4）。Apo E2/2和apo E3/2被归为E2 +组（n = 27）；apo E3纯合子被归为另一组（E3/3；n = 225），apo E4/3和apo E4/4受试者归为E4 +组（n = 66）。使用新开发的超声骨密度仪评估骨密度和骨质量，并测量血脂。
三组之间的年龄、体重指数和绝经年限无显著差异。E4 +组的总胆固醇水平、低密度脂蛋白胆固醇水平和载脂蛋白B水平最高，显著高于E2 +组。E4 +组的血浆脂蛋白(a)浓度显著高于其他两组。E4 +组的骨密度和质量的超声参数往往低于E2 +组。
apo E4等位基因与绝经后女性的高血浆胆固醇水平和骨结构的不良变化有关。
