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Small stress proteins: novel negative modulators of apoptosis induced independently of reactive oxygen species.

作者信息

Arrigo André-Patrick, Paul Catherine, Ducasse Cécile, Manero Florence, Kretz-Remy Carole, Virot Sophie, Javouhey Etienne, Mounier Nicole, Diaz-Latoud Chantal

机构信息

Laboratoire Stress Oxydant, Chaperons et Apoptose, Centre de Génétique Moléculaire et Cellulaire, CNRS UMR-5534, Université Claude Bernard Lyon-I, 69622 Villeurbanne, France.

出版信息

Prog Mol Subcell Biol. 2002;28:185-204. doi: 10.1007/978-3-642-56348-5_10.

DOI:10.1007/978-3-642-56348-5_10
PMID:11908059
Abstract
摘要

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Small stress proteins: novel negative modulators of apoptosis induced independently of reactive oxygen species.
Prog Mol Subcell Biol. 2002;28:185-204. doi: 10.1007/978-3-642-56348-5_10.
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Heat shock proteins--modulators of apoptosis in tumour cells.热休克蛋白——肿瘤细胞凋亡的调节因子
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Heat shock protein 27 regulates oxidative stress-induced apoptosis in cardiomyocytes: mechanisms via reactive oxygen species generation and Akt activation.热休克蛋白27调节氧化应激诱导的心肌细胞凋亡:通过活性氧生成和Akt激活的机制
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On the role of Hsp27 in regulating apoptosis.热休克蛋白27在调节细胞凋亡中的作用
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Biological reactive intermediates and mechanisms of cell death.
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Hsp27 negatively regulates cell death by interacting with cytochrome c.热休克蛋白27(Hsp27)通过与细胞色素c相互作用负向调节细胞死亡。
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Heat shock protein 27 prevents cellular polyglutamine toxicity and suppresses the increase of reactive oxygen species caused by huntingtin.热休克蛋白27可预防细胞多聚谷氨酰胺毒性,并抑制亨廷顿蛋白引起的活性氧增加。
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Small heat shock protein Hsp27 protects myosin S1 from heat-induced aggregation, but not from thermal denaturation and ATPase inactivation.小分子热休克蛋白Hsp27可保护肌球蛋白S1免受热诱导的聚集,但不能保护其免受热变性和ATP酶失活。
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Protective role of Hsp27 protein against gamma radiation-induced apoptosis and radiosensitization effects of Hsp27 gene silencing in different human tumor cells.Hsp27蛋白对γ射线诱导的细胞凋亡的保护作用以及Hsp27基因沉默在不同人类肿瘤细胞中的放射增敏作用。
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