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[围手术期意外低温的病因及后遗症]

[Etiology and sequelae of perioperative accidental hypothermia].

作者信息

Pannen B H J

机构信息

Anästhesiologischen Universitätsklinik Freiburg.

出版信息

Anaesthesiol Reanim. 2002;27(1):4-8.

Abstract

Accidental hypothermia is a frequent event during the perioperative period. Recent studies revealed a drop in core temperature of over 2 degrees C in more than 50% of all patients undergoing an operation. This drop in core temperature seems to be primarily due to the following factors. Anaesthesia prevents behavioural adaptations to changes in ambient temperature. Simultaneously, autonomic mechanisms of temperature control are suppressed by general as well as by neuraxial anaesthesia. The interthreshold range between core temperatures that trigger responses to warmth and to cold increases up to 20-fold. This is primarily due to a decrease in the cold response threshold. As a result, body core temperature of anaesthetized patients is primarily determined by the much lower temperature of the environment. On one hand, decreases in body temperatures may exert organ protective effects under certain conditions, e.g., by increasing ischemic tolerance. On the other hand, there is accumulating evidence that accidental perioperative hypothermia may also adversely affect organ function and outcome. For example, unfavourable effects of perioperative hypothermia on the immune defence, on the function of the coagulation system, on cardiovascular performance, as well as on postoperative recovery have been reported. Consequently, measures should be taken to actively control the perioperative heat balance of patients.

摘要

围手术期意外体温过低是一种常见情况。近期研究表明,超过50%的手术患者核心体温下降超过2摄氏度。核心体温下降似乎主要归因于以下因素。麻醉会阻碍机体对环境温度变化做出行为适应。同时,全身麻醉以及椎管内麻醉都会抑制体温调节的自主机制。触发机体对温暖和寒冷做出反应的核心体温阈值范围增大至20倍。这主要是由于冷反应阈值降低所致。因此,麻醉患者的体核温度主要取决于低得多的环境温度。一方面,在某些情况下,体温降低可能发挥器官保护作用;例如,通过提高缺血耐受性。另一方面,越来越多的证据表明围手术期意外体温过低也可能对器官功能和预后产生不利影响。例如,已有报道围手术期体温过低对免疫防御、凝血系统功能、心血管功能以及术后恢复均有不良影响。因此,应采取措施积极控制患者围手术期的热平衡。

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