Bundschuh R
Department of Physics, University of California at San Diego, La Jolla, California 92093-0319, USA.
Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Mar;65(3 Pt 1):031911. doi: 10.1103/PhysRevE.65.031911. Epub 2002 Mar 5.
A mapping is established between sequence alignment, one of the most commonly used tools of computational biology, at a certain choice of scoring parameters and the asymmetric exclusion process, one of the few exactly solvable models of nonequilibrium physics. The statistical significance of sequence alignments is characterized through studying the total hopping current of the discrete time and space version of the asymmetric exclusion process.
在计算生物学中最常用的工具之一——序列比对的特定评分参数选择与非平衡物理学中少数可精确求解的模型之一——非对称排除过程之间建立了一种映射关系。通过研究非对称排除过程的离散时间和空间版本的总跳跃电流来表征序列比对的统计显著性。
