Wecker L, Dettbran W D
Arch Int Pharmacodyn Ther. 1975 Oct;217(2):236-45.
Rats treated chronically with atropine or atropine and neostigmine showed marked alterations in the responsiveness of receptors at the neuromuscular junction. Receptors in the phrenic nerve-hemidiaphragm interacting with d-tubocurarine were unaffected by atropine but exhibited a supersensitivity after neostigmine administration. Succinylcholine-sensitive sites developed a subsensitivity with both atropine and neostigmine treatment. Acetylcholine-induced contractures in the denervated hemidiaphragm showed a hypersensitivity after both drug administrations, but responses to carbamylcholine were unaffected. It is suggested that there exists a heterogeneous population of receptors at the mammalian neuromuscular junction who can be identified by their responses to the effects of chronic drug application.
长期用阿托品或阿托品与新斯的明治疗的大鼠，其神经肌肉接头处受体的反应性出现明显改变。膈神经-半膈肌中与d-筒箭毒碱相互作用的受体不受阿托品影响，但在给予新斯的明后表现出超敏感性。琥珀酰胆碱敏感位点在阿托品和新斯的明治疗后均出现敏感性降低。去神经支配的半膈肌中乙酰胆碱诱导的挛缩在两种药物给药后均表现出超敏感性，但对氨甲酰胆碱的反应不受影响。提示在哺乳动物神经肌肉接头处存在异质性的受体群体，可通过它们对长期药物应用效应的反应来识别。
