敌敌畏与胆碱能系统：对大鼠组织中胆碱酯酶、乙酰胆碱及胆碱含量的影响
Dichlorvos and the cholinergic system: effects on cholinesterase and acetylcholine and choline contents of rat tissues.
作者信息
Modak A T, Stavinoha W B, Weintraub S T
出版信息
Arch Int Pharmacodyn Ther. 1975 Oct;217(2):293-301.
The inhibition of cholinesterase by 50 mg/kg/5 ml, p.o., dichlorvos and subsequent recovery of enzyme activity was uniform in all brain regions studied. This uniformity was not observed in liver, erythrocytes and plasma. Acetylcholine levels were elevated in brain areas from 48 to 171% at 15 minutes after treatment. However, a biphasic effect was seen on choline metabolism in the brain. The cortex was found to be more cholinergic than the striatum in terms of per cent increase in acetylcholine and choline.
按50毫克/千克/5毫升口服敌敌畏后，胆碱酯酶的抑制作用以及随后酶活性的恢复在所有研究的脑区中是一致的。在肝脏、红细胞和血浆中未观察到这种一致性。治疗后15分钟，脑区乙酰胆碱水平升高了48%至171%。然而，在脑中胆碱代谢上观察到了双相效应。就乙酰胆碱和胆碱的增加百分比而言，发现皮质比纹状体具有更高的胆碱能活性。
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