Potvin A R, Tourtellotte W W, Henderson W G, Snyder D N
Arch Phys Med Rehabil. 1975 Oct;56(10):439-42.
During the last five years, a battery of tests measuring neurological function called the Quantitative Examination of Neurological Function (QENF) has been greatly expanded. To evaluate more effectively the efficacy of clinical trials, the results of a study on reliability of test measures and on long- and short-term effects of learning are reported. Of the 113 test measures that were evaluated using 18 young adult normal subjects, only the fatigue and error measures, the vibration sense and two simulated activities of daily living tests were found unreliable. With respect to learning, the largest improvements in performance were found for arm-shoulder pursuit tracking, followed by many of the tests of coordination, particularly those requiring manual and/or finger dexterity. Only slight changes were found for tests of vision, strength, and speed of hand and foot. There were no important differences between short- and long-term learning. Considering this and other studies, patients are not likely to improve their performance appreciably by learning in a clinical trial.
在过去五年中，一系列名为神经功能定量检查（QENF）的神经功能测试得到了极大扩展。为了更有效地评估临床试验的疗效，本文报告了一项关于测试指标可靠性以及学习的长期和短期影响的研究结果。在使用18名年轻成年正常受试者评估的113项测试指标中，仅发现疲劳和误差指标、振动觉以及两项模拟日常生活活动测试不可靠。关于学习，在手臂 - 肩部追踪测试中发现表现改善最大，其次是许多协调性测试，特别是那些需要手部和/或手指灵活性的测试。在手眼视觉、力量以及手足速度测试中仅发现轻微变化。短期学习和长期学习之间没有重要差异。综合考虑本研究及其他研究，患者不太可能通过在临床试验中学习而显著提高其表现。
