Hodson J, Thompson J, al-Azzawi F
Gynaecology Research Group, Department of Obstetrics and Gynaecology, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, PO Box 65, Leicester LE2 7LX, UK.
Climacteric. 2000 Jun;3(2):119-24. doi: 10.3109/13697130009167613.
To determine the prevalence of headache in menopausal women and to assess factors that may influence headache at menopause and in women using hormone replacement therapy (HRT).
A questionnaire survey was performed on 1000 consecutive women attending Leicester Royal Infirmary menopause clinics. Weight, blood pressure and smoking status were also recorded.
Recurrent headache was common and reported by 850 women; 240 women reported a history of migraine. Most women (n = 617) had headaches more frequently than once monthly and 520 women had had at least one headache in the preceding week. Stress was the most common trigger factor (n = 704). A group of 'hormone-sensitive' women was identified (n = 259) whose headaches became worse at menopause and showed variable response to HRT. Logistic regression models showed reported history of migraine and more difficulty coping with stress to be strong predictors for worse headache at menopause and with HRT. Headache improved with age and increasing diastolic blood pressure. No other significant factors were identified.
Headache is a substantial problem at menopause and in HRT users. It is difficult to predict which women will develop worse headaches at menopause and with HRT, but a history of migraine and reduced coping with stress were significant factors in this group.
确定更年期女性头痛的患病率，并评估可能影响更年期及使用激素替代疗法（HRT）的女性头痛的因素。
对连续就诊于莱斯特皇家医院更年期诊所的1000名女性进行问卷调查。同时记录体重、血压和吸烟状况。
复发性头痛很常见，850名女性报告有头痛症状；240名女性有偏头痛病史。大多数女性（n = 617）头痛发作频率超过每月一次，520名女性在前一周至少有一次头痛。压力是最常见的触发因素（n = 704）。确定了一组“激素敏感型”女性（n = 259），她们的头痛在更年期时加重，对HRT的反应各不相同。逻辑回归模型显示，偏头痛病史和应对压力困难是更年期及使用HRT时头痛加重的有力预测因素。头痛随年龄增长和舒张压升高而改善。未发现其他显著因素。
头痛在更年期女性和使用HRT的女性中是一个严重问题。很难预测哪些女性在更年期及使用HRT时会出现更严重的头痛，但偏头痛病史和应对压力能力下降是该群体中的重要因素。
