Baizig Nehla M, Hamouda B, Asma K, Farhat B A, Abderahmen L, Omrane B H, Ahmed el M
Institut Salah Azaiz, Tunis.
Tunis Med. 2001 Oct;79(10):544-7.
The undifferentiated carcinoma of nasopharyngeal type (UCNT) is highly prevalent in South East Asia countries and has intermediate incidence in Tunisia, where Epstein-Barr virus constitutes one of the key factors of oncogenesis. Our preliminary results, in 3 patients with UCNT, show an elevated rate of EBV antibodies and a latent infection (type II) (expression of LMP and absence of ZEBRA by immunohistochemical reaction) and a positive staining with EBERs probe by in situ hybridation (ISH) in all cases. These results confirm a close association between EBV and tunisian UCNT. Moreover, the use of HIS technique for detection of EBERs constitutes an additional and formal argument of this association.
鼻咽型未分化癌（UCNT）在东南亚国家高度流行，在突尼斯发病率中等，其中爱泼斯坦-巴尔病毒是致癌的关键因素之一。我们对3例UCNT患者的初步结果显示，EBV抗体率升高且存在潜伏感染（II型）（通过免疫组化反应显示LMP表达且无ZEBRA），并且所有病例经原位杂交（ISH）检测EBERs探针均呈阳性染色。这些结果证实了EBV与突尼斯UCNT之间存在密切关联。此外，使用ISH技术检测EBERs构成了这种关联的又一确凿证据。
