缺乏修复复制的人细胞系的放射增敏作用
Radiosensitization of a human cell line lacking repair replication.
作者信息
Lee Y C, Kulhanian F, Byfield J E
出版信息
Basic Life Sci. 1975;5B:807-11. doi: 10.1007/978-1-4684-2898-8_61.
PMID:1191202
Abstract
A human cell line has been isolated that is deficient in X-ray-induced repair replication. The slope of the radiation survival curve is greater in the presence of the anthracycline antibiotic, adriamycin. The results suggest that radiosensitization by DNA-binding drugs is more probably related to DNA strand breakage phenomena than to the polymerase step of excision-repair.
摘要
已分离出一种人类细胞系，其在X射线诱导的修复复制方面存在缺陷。在蒽环类抗生素阿霉素存在的情况下，辐射存活曲线的斜率更大。结果表明，与DNA结合的药物所导致的放射增敏作用更可能与DNA链断裂现象有关，而非与切除修复的聚合酶步骤有关。
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