孕中期胎儿三体综合征孕妇血清妊娠相关血浆蛋白A和抑制素A水平
Second-trimester maternal pregnancy-associated plasma protein a and inhibin a levels in fetal trisomies.
作者信息
Watanabe Hideki, Hamada Hiromi, Yamada Naoki, Ogura Tsuyoshi, Yasuoka Mana Obata, Okuno Suzuka, Fujiki Yutaka, Sohda Sohda, Kubo Takeshi
机构信息
Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
出版信息
Fetal Diagn Ther. 2002 May-Jun;17(3):137-41. doi: 10.1159/000048026.
OBJECTIVE
The aim of this study was to determine whether fetal trisomy is associated with altered levels of second-trimester maternal pregnancy-associated plasma protein A (PAPP-A) and inhibin A.
METHODS
Maternal serum PAPP-A and inhibin A concentrations were measured at 15-17 weeks of gestation in 14 singleton pregnancies with fetal trisomy and in 56 matched pregnant controls.
RESULTS
PAPP-A levels in the trisomy group were significantly lower than in controls. The inhibin A level with fetal trisomy 21 was slightly higher than the control group, but levels were not different between trisomies 18 and 13 and controls.
CONCLUSION
Fetal trisomies 21, 18, and 13 are associated with a reduction in second-trimester maternal PAPP-A levels; trisomies 18 and 13 are not associated with increased inhibin A levels, unlike trisomy 21.
目的
本研究旨在确定胎儿三体是否与孕中期孕妇妊娠相关血浆蛋白A（PAPP-A）和抑制素A水平的改变有关。
方法
在14例单胎妊娠合并胎儿三体的孕妇及56例匹配的对照孕妇妊娠15至17周时，测定其血清PAPP-A和抑制素A浓度。
结果
三体组的PAPP-A水平显著低于对照组。21三体胎儿的抑制素A水平略高于对照组，但18三体和13三体与对照组之间的水平无差异。
结论
21、18和13三体胎儿与孕中期孕妇PAPP-A水平降低有关；与21三体不同，18三体和13三体与抑制素A水平升高无关。
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