来自大戟的细胞毒性二萜类化合物。
Cytotoxic diterpenoids from Euphorbia pekinensis.
作者信息
Kong Ling-Yi, Li Yi, Wu Xian-Li, Min Zhi-Da
机构信息
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, PR China.
出版信息
Planta Med. 2002 Mar;68(3):249-52. doi: 10.1055/s-2002-23132.
A new diterpenoid, named euphpekinensin, along with three known diterpenoids, was isolated from the roots of Euphorbia pekinensis for the first time and the structures were elucidated by spectral analysis. The 2D-NMR techniques such as 1H-1H COSY, HMQC, HMBC and NOESY spectra were mainly applied to determine the structure of the new diterpenoid. The four diterpenoids showed cytotoxic activity against human KB cells in vitro.
从大戟根中首次分离出一种名为京大戟二萜素的新二萜类化合物以及三种已知的二萜类化合物，并通过光谱分析阐明了其结构。主要应用二维核磁共振技术，如1H-1H COSY、HMQC、HMBC和NOESY谱来确定新二萜类化合物的结构。这四种二萜类化合物在体外对人KB细胞显示出细胞毒性活性。
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