来自乳浆大戟的新型大环二萜类化合物。

New macrocyclic diterpenoids from Euphorbia esula.

作者信息

Liu L G, Meng J C, Wu S X, Li X Y, Zhao X C, Tan R X

机构信息

Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing, People's Republic of China.

出版信息

Planta Med. 2002 Mar;68(3):244-8. doi: 10.1055/s-2002-23135.

DOI:10.1055/s-2002-23135

PMID:11914962

Abstract

The structures of two new macrocyclic jatrophane diterpenoid esters from the whole herb of Euphorbia esula, were established as 11,14-epoxy-3beta,5alpha,7beta,8alpha,9alpha,15beta-hexaacetoxy-12-oxo-13alphaH-jatropha-6(17)-ene (1) and 1alpha,3beta-diacetoxy-5alpha,7beta-dibenzoyloxy-9,14-dioxo-11beta,12alpha-epoxy-2alpha,8alpha,15beta-trihydroxy-13betaH-jatropha-6(17)-ene (2) by a combination of 1D- and 2D-NMR techniques as well as UV, IR and mass spectral data. Bioassay evaluation of all isolates against the human tumor cell lines (B16, KB, SMMC and BGC) indicated that ester 2 was cytotoxic to B16 with the IC50 value being 1.81 microg/ml. In addition, the irritant activity assay indicated that both diterpenoids were inactive (ID(24)50 > 100 microg/ear).

摘要

从大戟全草中分离得到两个新的大环麻风树烷二萜酯，通过一维和二维核磁共振技术以及紫外、红外和质谱数据，将其结构确定为11,14-环氧-3β,5α,7β,8α,9α,15β-六乙酰氧基-12-氧代-13αH-麻风树-6(17)-烯（1）和1α,3β-二乙酰氧基-5α,7β-二苯甲酰氧基-9,14-二氧代-11β,12α-环氧-2α,8α,15β-三羟基-13βH-麻风树-6(17)-烯（2）。对所有分离物针对人肿瘤细胞系（B16、KB、SMMC和BGC）进行生物活性测定，结果表明酯2对B16具有细胞毒性，IC50值为1.81μg/ml。此外，刺激性活性测定表明这两种二萜均无活性（ID(24)50>100μg/耳）。