苯妥英钠大剂量用药。
Macrodosage of phenytoin.
作者信息
Meredith C G, Kennedy M, Chinwah P M, Wade D N
出版信息
Med J Aust. 1979 Dec 1;2(11):584, 609. doi: 10.5694/j.1326-5377.1979.tb127196.x.
Abstract
Large doses (up to 1200 mg) of phenytoin were required to achieve therapeutic plasma concentrations and to control post-traumatic seizures in a 62-year-old woman. The elimination half-life of phenytoin was calculated to be 3.5 hours. Frequent monitoring of the plasma concentration was essential to optimize the therapeutic control and to avoid systemic toxicity.
摘要
为使一名62岁女性达到治疗性血浆浓度并控制创伤后癫痫发作，需要大剂量（高达1200毫克）的苯妥英。计算得出苯妥英的消除半衰期为3.5小时。频繁监测血浆浓度对于优化治疗控制和避免全身毒性至关重要。
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