一剂二甲基亚硝胺对后续剂量毒性以及对小鼠四氯化碳毒性的影响。
The effect of a dose of dimethylnitrosamine on the toxicity of a subsequent dose and on the toxicity of carbon tetrachloride in mice.
作者信息
Pound A W
出版信息
Br J Exp Pathol. 1975 Jun;56(3):271-5.
Abstract
Mice were given a first dose of dimethylnitrosamine (DMN) and the LD50 of a second dose determined at various times later. The total dose (sum of the 2 doses) tolerated under these conditions increased slowly as the interval between the 2 doses increased, to a maximum that was maintained until the 6th day. The LD50 of the second dose then returned slowly to normal by the 10th day. The data suggest that the biochemical lesion in DMN induced liver necrosis developed relatively slowly.
摘要
给小鼠注射第一剂二甲基亚硝胺（DMN），并在之后不同时间测定第二剂的半数致死量（LD50）。在这些条件下，随着两剂之间的间隔时间增加，所耐受的总剂量（两剂之和）缓慢增加，直至第6天达到最大值并维持不变。然后，第二剂的LD50在第10天时缓慢恢复至正常水平。这些数据表明，DMN诱导的肝坏死中的生化损伤发展相对缓慢。
相似文献
1
The effect of a dose of dimethylnitrosamine on the toxicity of a subsequent dose and on the toxicity of carbon tetrachloride in mice.
Br J Exp Pathol. 1975 Jun;56(3):271-5.
2
Protection by carbon tetrachloride against the toxic effects of dimethylnitrosamine in mice.
Br J Exp Pathol. 1975 Feb;56(1):77-82.
3
Partial hepatectomy and toxicity of dimethyl-nitrosamine and carbon tetrachloride, in relation to the carcinogenic action of dimethylnitrosamine.
Br J Cancer. 1975 Nov;32(5):596-603. doi: 10.1038/bjc.1975.266.
4
Diverse mechanisms of hepatocellular injuries due to chemicals: evidence in rats administered carbon tetrachloride or dimethylnitrosamine.
Br J Exp Pathol. 1975 Apr;56(2):103-12.
5
Reduction of carbon tetrachloride toxicity by prior administration of a single small dose in mice and rats.
Br J Exp Pathol. 1975 Apr;56(2):172-9.
6
Acute toxicity of dimethylnitrosamine in the presence of inhibitors of DMN demethylase.
Experientia. 1976 Apr 15;32(4):495-6. doi: 10.1007/BF01920817.
7
Decreased toxicity of dimethylnitrosamine in rats after treatment with carbon tetrachloride.
Pathology. 1973 Jul;5(3):233-42. doi: 10.3109/00313027309060840.
8
Effects of piperonyl butoxide on dimethylnitrosamine metabolism and toxicity in Swiss mice.
J Toxicol Environ Health. 1976 Sep;2(1):67-75. doi: 10.1080/15287397609529418.
9
Oxidative metabolism of dimethylnitrosamine: correlation with toxicity.
J Toxicol Environ Health. 1978 Jan;4(1):161-72. doi: 10.1080/15287397809529653.
10
Biphasic effect of colchicine on acute liver injury induced by carbon tetrachloride or by dimethylnitrosamine in mice.
J Hepatol. 1999 Nov;31(5):825-33. doi: 10.1016/s0168-8278(99)80283-9.
引用本文的文献
1
Matching donor to recipient in liver transplantation: Relevance in clinical practice.
World J Hepatol. 2013 Nov 27;5(11):603-11. doi: 10.4254/wjh.v5.i11.603.
本文引用的文献
1
The decomposition and toxicity of dialkylnitrosamines in rats.
Biochem J. 1962 Oct;85(1):72-91. doi: 10.1042/bj0850072.
2
Alterations in microsomal electron transport, oxidative N-demethylation and azo-dye cleavage in carbon tetrachloride and dimethylnitrosamine-induced liver injury.
Biochem J. 1967 Apr;103(1):55-64. doi: 10.1042/bj1030055.
3
Effects of feeding the carcinogen dimethylnitrosamine on its metabolism and methylation of DNA in the mouse.
Chem Biol Interact. 1972 Apr;4(5):321-7. doi: 10.1016/0009-2797(72)90086-5.
4
Protection by a small dose of carbon tetrachloride against the toxic effects of dimethylnitrosamine in rats.
Br J Exp Pathol. 1974 Apr;55(2):203-12.
5
[Protective action of hepatotoxic substances against lethal doses of a toxin from Amanita phalloides (phalloidin)].
Biochem Pharmacol. 1966 Oct;15(10):1589-93. doi: 10.1016/0006-2952(66)90202-4.
6
Carbon tetrachloride hepatotoxicity: an example of lethal cleavage.
CRC Crit Rev Toxicol. 1973 Nov;2(3):263-97. doi: 10.3109/10408447309082019.
7
Binding of 14 C-carbon tetrachloride to microsomal proteins in vitro and formation of CHC1 3 by reduced liver microsomes.
Xenobiotica. 1973 Jan;3(1):1-11. doi: 10.3109/00498257309151495.
Zotero 插件