二甲基亚硝胺在二甲基亚硝胺脱甲基酶抑制剂存在下的急性毒性

Acute toxicity of dimethylnitrosamine in the presence of inhibitors of DMN demethylase.

作者信息

Friedman M A, Sanders V

出版信息

Experientia. 1976 Apr 15;32(4):495-6. doi: 10.1007/BF01920817.

DOI:10.1007/BF01920817

Abstract

The LD50 of DMN was determined in groups of mice in the presence of inhibitors of DMN demethylase. Piperonyl butoxide, dibutylnitrosamine and nitrososarcosine had no effect on the acute toxicity of DMN. Diethylnitrosamine and DMN were markedly synergistic. All mice treated with 100 mg/kg diethylnitrosamine and 10.7 mg/kg DMN died. These results suggest that DMN demethylase may not be involved in the acute toxicity of DMN.

摘要

在存在二甲基亚硝胺脱甲基酶抑制剂的情况下，对小鼠组测定了二甲基亚硝胺（DMN）的半数致死剂量（LD50）。胡椒基丁醚、二丁基亚硝胺和亚硝基肌氨酸对DMN的急性毒性没有影响。二乙基亚硝胺和DMN具有明显的协同作用。所有用100mg/kg二乙基亚硝胺和10.7mg/kg DMN处理的小鼠均死亡。这些结果表明，DMN脱甲基酶可能不参与DMN的急性毒性。