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[儿童脑脊液分流管感染:预防与治疗]

[Infections of cerebrospinal fluid shunts in the child: prevention and treatment].

作者信息

Camboulives J, Meyrieux V, Léna G

机构信息

Département d'anesthésie-réanimation pédiatrique, hôpital d'enfants de la Timone, 13385 Marseille, France.

出版信息

Ann Fr Anesth Reanim. 2002 Feb;21(2):84-9. doi: 10.1016/s0750-7658(01)00500-7.

Abstract

Cerebrospinal fluid (CSF) shunting has developed into the mean method of treatment in children with hydrocephalus. Until the last decade, shunt infection was the most important cause of morbidity with a mean rate of 10%. Most of shunt infection (> 90%) are diagnosed within six months after surgery supporting a basic premise of direct contamination at the time of surgery. However, after applying stricter operative and perioperative protocols, some authors reported a dramatically decrease in the incidence of infectious complications. The overall annual risk of shunt infection in a paediatric neurosurgical unit is currently 1%. Risk factors are analysed with emphasis on the choice of preventive treatment. An outline of the protocol for shunt implantation is presented. There is no clearly defined role for prophylactic antibiotic medications in the prevention of shunt infection. The small sample sizes of prospective controlled clinical trials precluded sufficient statistical power. The conclusions of the meta-analyses are not sufficiently robust to resolve the controversy and it is not possible to make recommendations either for or against the use of prophylaxis in shunt surgery. The management of shunt infection is examined with emphasis on antibiotic therapy.

摘要

脑脊液分流术已发展成为治疗儿童脑积水的主要方法。直到过去十年,分流感染一直是发病率的最重要原因,平均发生率为10%。大多数分流感染(>90%)在术后六个月内被诊断出来,这支持了手术时直接污染的一个基本前提。然而,在应用更严格的手术和围手术期方案后,一些作者报告感染并发症的发生率显著下降。目前,儿科神经外科病房分流感染的总体年度风险为1%。分析了危险因素,重点是预防性治疗的选择。介绍了分流植入术的方案概述。预防性抗生素药物在预防分流感染方面没有明确的作用。前瞻性对照临床试验的样本量较小,缺乏足够的统计效力。荟萃分析的结论不够有力,无法解决争议,也无法就是否在分流手术中使用预防措施提出建议。重点讨论了分流感染的管理,尤其是抗生素治疗。

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