Hlavacek William S, Percus Jerome K, Percus Ora E, Perelson Alan S, Wofsy Carla
Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
Math Biosci. 2002 Apr;176(2):185-202. doi: 10.1016/s0025-5564(02)00091-3.
In HIV-infected patients, large quantities of HIV are associated with follicular dendritic cells (FDCs) in lymphoid tissue. During antiretroviral therapy, most of this virus disappears after six months of treatment, suggesting that FDC-associated virus has little influence on the eventual outcome of long-term therapy. However, a recent theoretical study using a stochastic model for the interaction of HIV with FDCs indicated that some virus may be retained on FDCs for years, where it can potentially reignite infection if treatment is interrupted. In that study, an approximate expression was used to estimate the time an individual virion remains on FDCs during therapy. Here, we determine the conditions under which this approximation is valid, and we develop expressions for the time a virion spends in any bound state and for the effect of rebinding on retention. We find that rebinding, which is influenced by diffusion, may play a major role in retention of HIV on FDCs. We also consider the possibility that HIV is retained on B cells during therapy, which like FDCs also interact with HIV. We find that virus associated with B cells is unlikely to persist during therapy.
在感染HIV的患者中，大量HIV与淋巴组织中的滤泡树突状细胞（FDC）相关。在抗逆转录病毒治疗期间，大部分这种病毒在治疗六个月后消失，这表明与FDC相关的病毒对长期治疗的最终结果影响很小。然而，最近一项使用HIV与FDC相互作用的随机模型的理论研究表明，一些病毒可能会在FDC上保留数年，如果治疗中断，它有可能重新引发感染。在该研究中，使用了一个近似表达式来估计单个病毒粒子在治疗期间留在FDC上的时间。在这里，我们确定该近似有效的条件，并推导出病毒粒子在任何结合状态下停留的时间以及重新结合对保留的影响的表达式。我们发现，受扩散影响的重新结合可能在HIV在FDC上的保留中起主要作用。我们还考虑了治疗期间HIV保留在B细胞上的可能性，B细胞与FDC一样也与HIV相互作用。我们发现与B细胞相关的病毒在治疗期间不太可能持续存在。
