Arquette Matthew, Wasserman Todd, Govindan Ramaswamy, Garfield David, Senzer Neil, Gillenwater Heidi, Socinski Mark
Washington University, St Louis, MO 63110, USA.
Semin Radiat Oncol. 2002 Jan;12(1 Suppl 1):59-61. doi: 10.1053/srao.2002.31375.
For limited-stage small cell lung cancer, twice-daily radiation with concurrent chemotherapy improves survival rate, but has dose-limiting esophageal toxicity. The authors studied 34 patients treated with amifostine in an attempt to decrease the incidence and grade of esophagitis. The results indicate that there was no reduction in toxicity, but the authors were able to maintain the high complete response rate that had been reported previously. These results differ from the use of amifostine in non-small cell lung cancer in which there is the observation of esophageal protection.
对于局限期小细胞肺癌，每日两次放疗联合同步化疗可提高生存率，但存在剂量限制性食管毒性。作者研究了34例接受氨磷汀治疗的患者，试图降低食管炎的发生率和严重程度。结果表明，毒性并未降低，但作者能够维持先前报道的高完全缓解率。这些结果与氨磷汀在非小细胞肺癌中的应用不同，在非小细胞肺癌中观察到了食管保护作用。
