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[胸腺作为刺激抗体形成的体液因子来源的研究]

[Study of the thymus as a source of humoral factors stimulating antibody formation].

作者信息

Giulling E V, Nikol'skiĭ I S

出版信息

Biull Eksp Biol Med. 1975 Apr;79(4):82-5.

PMID:1191774
Abstract

A fraction stimulating antibody formation in neonatal animals was obtained in separation of the calf thymus extract (1A) prepared by the method of Goldstein et al. on a column with Sephadex G-25 (fine). Testing of the activity of analogous fractions of the extracts of calf tonsils, spleen, lymph nodes and the liver led to a supposition that the thymus was the only source of specific humoral factor stimulating antibody formation, which could accumulate in the peripheral lymphoid formations. Low activity of tonsillar extracts failed to confirm the hypothesis on the role played by the tonsils as the central immunity organ similar to the bursa Fabricii.

摘要

通过用戈尔茨坦等人的方法制备的小牛胸腺提取物(1A)在装有葡聚糖凝胶G - 25(细)的柱上进行分离,获得了一种能刺激新生动物抗体形成的组分。对小牛扁桃体、脾脏、淋巴结和肝脏提取物的类似组分的活性进行检测后推测,胸腺是刺激抗体形成的特异性体液因子的唯一来源,该因子可在周围淋巴组织中蓄积。扁桃体提取物活性较低,这未能证实扁桃体作为类似于法氏囊的中枢免疫器官所起作用的假说。

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