Wickramasinghe S N, Williams G, Saunders J, Durston J H
Br Med J. 1975 Oct 18;4(5989):136-7. doi: 10.1136/bmj.4.5989.136.
The results of deoxyuridine suppression tests on the bone marrow cells of 14 patients on anticonvulsant drugs, 11 of whom had evidence of megaloblastic erythropoiesis, indicated that the megaloblastic changes and macrocytosis encountered in treated epileptics are often not caused either by folate deficiency or by drug-induced impairment of the 5, 10-methylenetetrahydrofolate-dependent methylation of deoxyuridylate to thymidylate. A folate-related abnormality in the methylation of deoxyuridylate was found in only two of the 11 patients with megaloblastic erythropoiesis.
对14名服用抗惊厥药物患者的骨髓细胞进行脱氧尿苷抑制试验的结果显示，其中11名患者有巨幼红细胞生成的证据，这表明接受治疗的癫痫患者中出现的巨幼细胞改变和大细胞症通常既不是由叶酸缺乏引起的，也不是由药物诱导的依赖5,10 - 亚甲基四氢叶酸的脱氧尿苷酸甲基化生成胸苷酸的过程受损所致。在11名有巨幼红细胞生成的患者中，仅2名患者发现了与叶酸相关的脱氧尿苷酸甲基化异常。
