Durand G, Hubert M F, Kuno H, Cook W O, Stabinski L G, Darbes J, Virat M
MSD-Chibret, Riom, France.
Comp Med. 2001 Apr;51(2):176-9.
A spontaneous focal polar anterior subcapsular lenticular opacity characterized by focal epithelial proliferation was found in Charles River Sprague-Dawley rats from various breeding facilities around the world (France, Japan, and the United States). The incidence of this change slightly increased with age up to a maximal incidence of 9.8% in 28- to 35-week-old male rats (French source). Over that period, there was little change in the size of the opacity; however some rats that were examined over longer periods (more than 2 years of age) developed secondary anterior cortical changes, and rarely, histologic findings of pigmentation and/or mineralization. The lenticular change was present throughout the life of the animals and had no sex predilection; mode of inheritance was not investigated. Due to its small size, this lens opacity is more easily identified by use of slit lamp biomicroscopy than by use of indirect ophthalmoscopy, and serial sections of the eye aid in locating it for histologic evaluation.
在来自世界各地（法国、日本和美国）不同繁殖设施的查尔斯河斯普拉格-道利大鼠中，发现了一种以局灶性上皮细胞增殖为特征的自发性局灶性极性前囊下晶状体混浊。这种变化的发生率随年龄略有增加，在28至35周龄的雄性大鼠（法国来源）中最高发生率为9.8%。在此期间，混浊大小变化不大；然而，一些接受更长时间检查（超过2岁）的大鼠出现了继发性前皮质变化，很少有色素沉着和/或矿化的组织学表现。晶状体变化在动物的整个生命过程中都存在，没有性别偏好；未研究遗传方式。由于其尺寸较小，这种晶状体混浊通过裂隙灯生物显微镜检查比间接检眼镜更容易识别，眼睛的连续切片有助于定位其进行组织学评估。
