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川崎病的冠状动脉搭桥术

Coronary artery bypass grafting for Kawasaki disease.

作者信息

Gotteiner N, Mavroudis C, Backer C L, Pahl E, Duffy C E, Dalzell V, Shulman S T

机构信息

Department of Pediatrics, Children's Memorial Hospital, Northwestern University Medical School, Chicago, IL 60614, USA.

出版信息

Pediatr Cardiol. 2002 Jan-Feb;23(1):62-7. doi: 10.1007/s00246-001-0015-1. Epub 2002 Feb 19.

Abstract

Five patients with a history of Kawasaki disease underwent coronary revascularization at Children's Memorial Hospital (1988-2000). Acute disease occurred at 11 weeks to 5 years of age and revascularization procedures were performed at 8 months to 12 years (mean 6 years; interval from disease onset 5 months to 9 years). Surgical indications included abnormal stress testing with angiographic confirmation of severe coronary artery stenosis (n = 3), severe coronary artery stenosis with echocardiographic evidence of intracoronary thrombus (n = 1), and ischemic electrocardiogram changes and ventricular tachycardia during angiography (n = 1). All revascularization procedures used internal thoracic arteries including one free internal thoracic artery graft. There were no postoperative deaths (follow-up 1 month to 11 years). All patients are asymptomatic. One patient developed myocardial ischemia 4 years postoperatively with occlusion of the circumflex coronary artery (not previously grafted). This was treated successfully with percutaneous coronary angioplasty and stent placement. All grafts are patent with the exception of a single right internal thoracic artery graft which underwent involution 30 months postprocedure with concurrent recannulization of the right coronary artery. Coronary revascularization should be considered in the young patient with severe coronary abnormalities secondary to Kawasaki disease.

摘要

五名有川崎病病史的患者在儿童纪念医院接受了冠状动脉血运重建术(1988 - 2000年)。急性病发生于11周龄至5岁,血运重建手术在8个月至12岁时进行(平均6岁;从疾病发作起间隔5个月至9年)。手术指征包括应激试验异常且血管造影证实有严重冠状动脉狭窄(n = 3)、严重冠状动脉狭窄且超声心动图有冠状动脉内血栓证据(n = 1),以及血管造影期间出现缺血性心电图改变和室性心动过速(n = 1)。所有血运重建手术均使用胸廓内动脉,包括一根游离胸廓内动脉移植物。无术后死亡(随访1个月至11年)。所有患者均无症状。一名患者术后4年出现心肌缺血,回旋支冠状动脉闭塞(此前未进行移植)。经皮冠状动脉腔内血管成形术和支架置入术成功治疗了该疾病。除一根右胸廓内动脉移植物在术后30个月出现退化并伴有右冠状动脉同时再通外,所有移植物均通畅。对于继发于川崎病的严重冠状动脉异常的年轻患者,应考虑进行冠状动脉血运重建术。

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