Brewer M, Baze W, Hill L, Utzinger U, Wharton J T, Follen M, Khan-Dawood F, Satterfield W
Department of Veterinary Sciences Science Park, The University of Texas M. D. Anderson Cancer Center, Houston 7030, USA.
Comp Med. 2001 Oct;51(5):424-9.
The objective of the study reported here was to explore whether a nonhuman primate model could be developed for chemoprevention of ovarian cancer.
An initial feasibility trial was done with three monkeys to determine tolerance for these drugs and for acquisition of surgical ovarian biopsy specimens. In the study, 19 female adult Macacca mulatta (rhesus macaques) were given fenretinide (4HPR) oral contraceptive (OCP), the combination of 4HPR+OCP, or no medication for three months. Laparotomy was performed before and after drug administration, and ovarian biopsy specimens were obtained to evaluate the potential for this animal as a model for ovarian cancer chemoprevention, as well as evaluating fluorescence spectroscopy and other potential biomarkers for ovarian cancer prevention studies.
The monkeys tolerated the drugs, surgeries, and acquisition of multiple ovarian biopsy specimens with resultant minimal morbidity. On initial data analysis, fluorescence spectroscopy was the marker that appeared the most promising.
On the basis of results of this study, this model merits further investigation. The rhesus monkey is an excellent candidate for a nonhuman primate model for ovarian cancer chemoprevention.
本文报道的这项研究的目的是探索是否可以开发一种用于卵巢癌化学预防的非人灵长类动物模型。
对三只猴子进行了初步可行性试验，以确定它们对这些药物的耐受性以及获取手术卵巢活检标本的情况。在该研究中，19只成年雌性猕猴被给予非维生素A酸（4HPR）、口服避孕药（OCP）、4HPR与OCP的组合，或三个月不服用任何药物。在给药前后进行剖腹手术，并获取卵巢活检标本，以评估该动物作为卵巢癌化学预防模型的潜力，以及评估荧光光谱和其他用于卵巢癌预防研究的潜在生物标志物。
猴子耐受了药物、手术以及获取多个卵巢活检标本，由此导致的发病率极低。在初步数据分析中，荧光光谱是最有前景的标志物。
基于本研究结果，该模型值得进一步研究。恒河猴是用于卵巢癌化学预防的非人灵长类动物模型的极佳候选者。
