Chikui Toru, Yuasa Kenji, Maemura Satoshi, Kanda Shigenobu
Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Kyushu University, Fukuoka, Japan.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Mar;93(3):350-7. doi: 10.1067/moe.2002.121388.
Experimental models of lymph node metastasis were developed for Doppler sonography.
Cervical lymph node (LN) metastasis was induced by the implantation of a VX-2 tumor on the oral floor of 10 rabbits. Twenty metastatic LNs were observed weekly by power Doppler sonography, and the presence of an avascular area and the peripheral vessels were evaluated. The time-averaged maximum velocity (TAMx) at the hilum was also measured.
The percentage of the metastatic LNs presenting with an avascular area increased over time. The peripheral vessels were detected in 14 of 20 LNs. The peak time of the TAMx significantly correlated to that of the initial detection of the avascular area.
In the beginning, metastatic LNs were depicted as hypervascular structures while the TAMx at the hilum increased. Later, an avascular area was detected and the TAMx at the hilum decreased, which resulted in a blood supply to the node from the peripheral vessels.
建立用于多普勒超声检查的淋巴结转移实验模型。
通过在10只兔的口腔底部植入VX-2肿瘤诱导颈部淋巴结（LN）转移。每周用能量多普勒超声观察20个转移性淋巴结，评估有无无血管区及外周血管情况。同时测量淋巴结门部的时间平均最大流速（TAMx）。
出现无血管区的转移性淋巴结百分比随时间增加。20个淋巴结中有14个检测到外周血管。TAMx的峰值时间与无血管区最初检测的峰值时间显著相关。
起初，转移性淋巴结表现为高血管结构，同时淋巴结门部的TAMx增加。后来，检测到无血管区，淋巴结门部的TAMx降低，从而导致由外周血管为淋巴结供血。
