Shimokawa Takayoshi, Saitoh Minoru, Kojima Yumi, Takeyama Hideo
Department of Internal Medicine, Nagoya Ekisaikai Hospital.
Rinsho Ketsueki. 2002 Feb;43(2):112-6.
We report a case of myeloid/NK cell precursor acute leukemia, which was successfully treated with allogeneic peripheral blood stem cell transplantation (allo PBSCT). A 31-year-old woman was admitted to our hospital with general fatigue, anorexia and leukocytosis. Bone marrow aspiration showed infiltration of many atypical blasts. She was diagnosed as having myeloid/NK cell precursor acute leukemia by morphological and immunohistochemical analysis. Complete remission was achieved by induction chemotherapy, but as myeloid/NK cell precursor acute leukemia is reported to have an extremely poor prognosis due to frequent relapse, the patient underwent allo PBSCT from her HLA-identical father, together with a myeloablative conditioning regimen. She suffered several transplantation-related complications including acute graft versus host disease (grade II) and ischemic enterocolitis associated with thrombotic microangiopathy, but these were overcome by supportive therapy. She was discharged on day 168 after allo PBSCT, and so far there has been no evidence of relapse during a follow-up period of 15 months.
我们报告了一例髓系/自然杀伤细胞前体急性白血病患者，其通过异基因外周血干细胞移植（allo PBSCT）获得成功治疗。一名31岁女性因全身乏力、厌食和白细胞增多症入院。骨髓穿刺显示有许多非典型原始细胞浸润。通过形态学和免疫组织化学分析，她被诊断为髓系/自然杀伤细胞前体急性白血病。诱导化疗实现了完全缓解，但由于据报道髓系/自然杀伤细胞前体急性白血病因频繁复发预后极差，该患者接受了来自其 HLA 配型相合父亲的 allo PBSCT，并采用了清髓性预处理方案。她出现了几种与移植相关的并发症，包括急性移植物抗宿主病（II级）和与血栓性微血管病相关的缺血性小肠结肠炎，但通过支持治疗得以克服。她在 allo PBSCT 后第168天出院，到目前为止，在15个月的随访期内没有复发迹象。
