布氏冈比亚锥虫的遗传变异性：科特迪瓦人类非洲锥虫病患者中不同基因型传播的证据。
Genetic variability within Trypanosoma brucei gambiense: evidence for the circulation of different genotypes in human African trypanosomiasis patients in Côte d'Ivoire.
作者信息
Truc Philippe, Ravel Sophie, Jamonneau Vincent, N'Guessan Paul, Cuny Gérard
机构信息
Institut de Recherche pour le Développement, Département Sociétés et Santé, Laboratoire de Recherche et de Coordination sur les Trypanosomoses, UR 035 Trypanosomoses Africaines, Campus International de Baillarguet, 34398 Montpellier, France.
出版信息
Trans R Soc Trop Med Hyg. 2002 Jan-Feb;96(1):52-5. doi: 10.1016/s0035-9203(02)90237-3.
For 23 Ivoirian patients infected by Trypanosoma-brucei gambiense, isolation and genetic characterization using PCR and microsatellite primers were performed (in 1996-99) using 2 different isolates (A and B) from each patient. When using TBDAC 1/2, 7 genotypes were observed, and DNAs A and B for 2 patients were different. This might be the first evidence of the presence of 2 different genotypes of T. b. gambiense group 1 in the same patient.
对于23名感染布氏冈比亚锥虫的科特迪瓦患者，（于1996年至1999年）使用来自每位患者的2种不同分离株（A和B）进行了PCR和微卫星引物的分离及基因特征分析。使用TBDAC 1/2时，观察到7种基因型，2名患者的DNA A和B不同。这可能是同一患者中存在2种不同基因型的布氏冈比亚锥虫第1组的首个证据。
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