Zhou W, Carpenter G
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146, USA.
Inflamm Res. 2002 Feb;51(2):91-101. doi: 10.1007/BF02684009.
ErbB-4 is a receptor tyrosine kinase that is activated by the binding of specific growth factors to its ectodomain. In addition to the initiation of signal transduction pathways that direct cell responses, such as proliferation or differentiation, this receptor is subject to ligand-dependent trafficking events. The signal transduction events are controlled by ligand-dependent activation of the receptor tyrosine kinase activity, which results in receptor autophosphorylation and the tyrosine phosphorylation of other cellular proteins. The trafficking events include migration into and out of membrane microdomains, entry into internalization pathways and endocytosis, plus proteolytic fragmentation.
ErbB-4是一种受体酪氨酸激酶，通过特定生长因子与其胞外结构域结合而被激活。除了启动指导细胞反应（如增殖或分化）的信号转导途径外，该受体还会发生依赖配体的运输事件。信号转导事件由受体酪氨酸激酶活性的配体依赖性激活控制，这导致受体自身磷酸化以及其他细胞蛋白的酪氨酸磷酸化。运输事件包括移入和移出膜微区、进入内化途径和内吞作用，以及蛋白水解片段化。
