氮卓斯汀和色甘酸可缩短大鼠体内IgE的分布半衰期。
Azelastine and suplatast shorten the distribution half-life of IgE in rats.
作者信息
Hanashiro Kazuhiko, Tokeshi Yoshihiro, Nakasone Toshiyuki, Sunagawa Masanori, Nakamura Mariko, Kosugi Tadayoshi
机构信息
1st Department of Physiology, School of Medicine, University of the Ryukyus, Nishihara, Okinawa, Japan.
出版信息
Mediators Inflamm. 2002 Feb;11(1):61-4. doi: 10.1080/09629350210310.
We aim to clarify whether suplatast and azelastine (anti-allergic drugs) can shorten the half-life of imnunoglobulin E (IgE) in the circulating blood. Thirty Wistar rats were divided into six groups. Distilled water or anti-allergic drugs were given orally for 6 days after the first sensitization. Two milligrams of monoclonal dinitrophenyl (DNP)-specific rat IgE was administered to the rats, which had been given suplatast or azelastine orally. The level of DNP-specific rat IgE in the serum was estimated by IgE-capture enzyme-linked immunosorbent assay, and the turnover of IgE was analyzed from its pharmacokinetic parameters. The elimination half-life of rat IgE was about 12 h irrespective of the sensitized state. The intercompartmental rate constants (Kct and Ktc) in the suplatast-administered or azelastine-administered group were larger than those of the distilled water-administered group under non-sensitized conditions. These findings suggested that the anti-allergic drugs used in the present study facilitated the excretion of IgE from the circulation in rats.
我们旨在阐明色甘酸二钠和氮卓斯汀（抗过敏药物）是否能够缩短循环血液中免疫球蛋白E（IgE）的半衰期。30只Wistar大鼠被分为6组。首次致敏后口服蒸馏水或抗过敏药物6天。向已口服色甘酸二钠或氮卓斯汀的大鼠体内注射2毫克单克隆二硝基苯基（DNP）特异性大鼠IgE。通过IgE捕获酶联免疫吸附测定法评估血清中DNP特异性大鼠IgE的水平，并根据其药代动力学参数分析IgE的周转率。无论致敏状态如何，大鼠IgE的消除半衰期约为12小时。在未致敏条件下，色甘酸二钠给药组或氮卓斯汀给药组的隔室间速率常数（Kct和Ktc）大于蒸馏水给药组。这些发现表明，本研究中使用的抗过敏药物促进了大鼠体内IgE从循环中的排泄。
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