对接受氯磺丙脲、卡马西平或氯贝丁酯治疗的神经垂体性尿崩症患者给予血管加压素后出现的反常利尿。

Paradoxical diuresis after vasopressin administration to patients with neurohypophyseal diabetes insipidus treated with chlorpropamide, carbamazepine or clofibrate.

Meinders A E, van Leeuwen A M, Borst J G, Cejka V

Clin Sci Mol Med. 1975 Oct;49(4):283-90. doi: 10.1042/cs0490283.

Abstract

Chlorpropamide, carbamazepine and clofibrate have an antidiuretic action in patients with neurohypophyseal diabetes insipidus which is qualitatively similar to that of antidiuretic hormone (ADH). 2. An additive antidiuretic effect is produced by combination of chlorpropamide and carbamazepine with small dosages of ADH. 3. After an immediate and transient antidiuresis, a single intravenous bolus injection of lysine vasopressin given during treatment with chlorpropamide, chlorpropamide with a continuous intravenous infusion of lysine vasopressin, carbamazepine or clofibrate, resulted in increased water diuresis for 12-24 h or longer. 4. This paradoxical diuresis was not observed during treatment with chlorothiazide. 5. It is suggested that the antidiuretic action of chlorpropamide, carbamazepine and clofibrate is localized at the receptor site for ADH in the distal renal tubular cell.

摘要

氯磺丙脲、卡马西平和氯贝丁酯对神经垂体性尿崩症患者具有抗利尿作用，其性质与抗利尿激素（ADH）相似。2. 氯磺丙脲和卡马西平与小剂量ADH联合使用可产生相加的抗利尿作用。3. 在氯磺丙脲、氯磺丙脲与持续静脉输注赖氨酸加压素、卡马西平或氯贝丁酯治疗期间，单次静脉推注赖氨酸加压素后，立即出现短暂抗利尿作用，随后出现12 - 24小时或更长时间的水利尿增加。4. 氯噻嗪治疗期间未观察到这种矛盾性利尿。5. 提示氯磺丙脲、卡马西平和氯贝丁酯的抗利尿作用定位于远端肾小管细胞中ADH的受体部位。