Dobrzanski S, Doggett N S
Psychopharmacology (Berl). 1979;66(3):297-300. doi: 10.1007/BF00428323.
Pimozide was a potent antagonist of (+)amphetamine, diethylpropion, mazindol and phentermine anorexia in the mouse. Phentolamine and propranolol produced no such antagonism, but either potentiated or had no effect on the drug-induced anorexia. Although the mechanism of action of the four anorectic agents appears to involve dopamine receptor agonist activity, an antagonist or partial agonist effect at noradrenergic receptors may also be involved.
匹莫齐特是小鼠体内（+）苯丙胺、二乙丙胺苯丙酮、马吲哚和苯丁胺致厌食作用的强效拮抗剂。酚妥拉明和普萘洛尔没有这种拮抗作用，但要么增强药物诱导的厌食作用，要么对其没有影响。尽管这四种厌食剂的作用机制似乎涉及多巴胺受体激动剂活性，但去甲肾上腺素能受体的拮抗剂或部分激动剂作用也可能参与其中。
